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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(09) [September 2005] >
| Title: | Kinetics and mechanism of the oxidation of some  -amino acids by benzyltrimethylammonium tribromide |
| Authors: | Garg, Dimple
Kothari, Seema |
| Keywords: | -amino acids
benzyltrimethylammonium tribromide
aldehydes
Michaelis-Menten type kinetics
thermodynamic parameters
perdeuterioglycine
kinetic isotope effect |
| Issue Date: | Sep-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 B 33/00, C 07 C 211/00 |
| Abstract: | The oxidation of nine -amino acids by benzyltrimethylammonium tribromide (BTMAB), in
aqueous acetic acid, leads to the formation of the corresponding aldehydes. The
reaction is first order with respect to BTMAB. Michaelis-Menten type kinetics
are observed with respect to the amino acids. The thermodynamic parameters for
the complex formation and the activation parameters for the decomposition of
complex have been determined. An addition of benzyltrimethylammonium ion does
not affect the rate. The oxidation of perdeuterioglycine shows the absence of a
kinetic isotope effect (kH/kD = 1.05 at 313 K). The
effect of solvent composition indicates that the reaction rate increases with
an increase in the polarity of the medium. The reaction is susceptible to both
polar and steric effects of the substituents. Suitable mechanism has been
proposed. |
| Page(s): | 1909-1914 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(09) [September 2005]
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