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Title: Synthesis and characterisation of isoquinolinyl quinazolines and a study of their antiviral and antifungal activities
Authors: Pandey, V K
Pathak, L P
Mishra, S K
Keywords: Isoquinolinyl quinazolines
Antiviral activity
antifungal activity
Issue Date: Sep-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 215/00 //A 61 P 31/10, 31/12</b>
Abstract: Anthranilic acid on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3<i>H</i>-benzoxazines <b>1</b> which reacts with <i>p-</i>aminobenzoic acid to afford 2-aryl-3<i>-p-</i>carboxylatophenyl-4-oxo-3<i>H</i>-quinazolines <b>2</b>. Interaction of <b>2</b> with benzoin in the presence of polyphosphoric acid results 2-aryl-3-(3',-4'-diphenyl­isocoumarinyl)-4-oxo-3<i>H</i>-quinazolines <b>3</b>, which on reaction with 2-amino-5-aralkyl-1,3,4-thiadiazoles yield 2-aryl-3-[5'-aralkyl-1',3',4'-thiadiazolyl-{2'-(3'',4''-diphenyl-1"-oxo-isoquino­linyl)}]-4-oxo-3<i>H</i>-quinazolines <b>4</b>. The antifungal and antiviral activities of <b>4</b> have been reported.
Description: 1940-1943
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(09) [September 2005]

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