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IJC-B Vol.44B(09) [September 2005] >

Title: Synthesis and characterisation of isoquinolinyl quinazolines and a study of their antiviral and antifungal activities
Authors: Pandey, V K
Pathak, L P
Mishra, S K
Keywords: Isoquinolinyl quinazolines
Antiviral activity
antifungal activity
Issue Date: Sep-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D 215/00 //A 61 P 31/10, 31/12
Abstract: Anthranilic acid on treatment with an aromatic acid chloride in pyridine gives 2-aryl-4-oxo-3H-benzoxazines 1 which reacts with p-aminobenzoic acid to afford 2-aryl-3-p-carboxylatophenyl-4-oxo-3H-quinazolines 2. Interaction of 2 with benzoin in the presence of polyphosphoric acid results 2-aryl-3-(3',-4'-diphenyl¬≠isocoumarinyl)-4-oxo-3H-quinazolines 3, which on reaction with 2-amino-5-aralkyl-1,3,4-thiadiazoles yield 2-aryl-3-[5'-aralkyl-1',3',4'-thiadiazolyl-{2'-(3'',4''-diphenyl-1"-oxo-isoquino¬≠linyl)}]-4-oxo-3H-quinazolines 4. The antifungal and antiviral activities of 4 have been reported.
Page(s): 1940-1943
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(09) [September 2005]

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