18-Jun-2013
11:12:36 IST
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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(08) [August 2005] >
| Title: | Synthesis and anticancer activity studies on some 2-chloro-1,4-bis-(5-substituted-1,3,4-oxadiazol-2-ylmethyleneoxy) phenylene derivatives |
| Authors: | Holla, B Shivarama
Poojary, K Narayana
Bhat, K Subrahmanya
Ashok, Mithun
Poojary, Boja |
| Keywords: | 1,3,4-Oxadiazoles
1,3,4-oxadiazole-2-thione
anticancer activity
GI50 values |
| Issue Date: | Aug-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 271/10 // A61 P 35/00 |
| Abstract: | 2-Chloro-1,4-phenylenedioxy-bis-acetyl
hydrazine 1 on reacting with
aromatic carboxylic acids in the presence of phosphorus oxychloride affords
2-chloro-bis-1,3,4-oxadiazoles 3a-f and 4a-d. Aroyl hydrazine 1 on reacting with carbon disulphide under basic condition gives
oxadiazole-2-thione 2. Three out of
four tested compounds show anticancer activity in the primary anticancer assay.
These compounds have been extensively screened against a panel of sixty cancer
cell lines derived from leukemia, lung, colon, CNS, melanoma, ovarian, renal,
prostate and breast cancer, respectively. It is interesting to note that
compounds 3d and 3f show significant anticancer activity
against most of the cell lines with GI50 values <100 μM concentrations. |
| Page(s): | 1669-1673 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(08) [August 2005]
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