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Title: Synthesis and anticancer activity studies on some 2-chloro-1,4-bis-(5-substituted-1,3,4-oxadiazol-2-ylmethyleneoxy) phenylene derivatives
Authors: Holla, B Shivarama
Poojary, K Narayana
Bhat, K Subrahmanya
Ashok, Mithun
Poojary, Boja
Keywords: 1,3,4-Oxadiazoles
anticancer activity
GI50 values
Issue Date: Aug-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 271/10 // A61 P 35/00</b>
Abstract: 2-Chloro-1,4-phenylenedioxy-bis-acetyl hydrazine <b style="">1</b> on reacting with aromatic carboxylic acids in the presence of phosphorus oxychloride affords 2-chloro-bis-1,3,4-oxadiazoles <b style="">3a-f </b>and<b> 4a-d</b>. Aroyl hydrazine<b style=""> 1 </b>on reacting with carbon disulphide under basic condition gives oxadiazole-2-thione <b style="">2</b>. Three out of four tested compounds show anticancer activity in the primary anticancer assay. These compounds have been extensively screened against a panel of sixty cancer cell lines derived from leukemia, lung, colon, CNS, melanoma, ovarian, renal, prostate and breast cancer, respectively. It is interesting to note that compounds <b style="">3d </b>and <b style="">3f</b> show significant anticancer activity against most of the cell lines with GI50 values <100 μM concentrations.
Description: 1669-1673
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(08) [August 2005]

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