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Title: Synthesis and anti-inflammatory activity of 4-(5'-acetyl-6'-hydroxy -3'-methyl-benzofuran-2'-yl) coumarin and 6-acetyl-3, 7-dimethyl-2-(coumarin-4'-yl) furo [3,2-<i style="">g</i>] chromen-5-one
Authors: Ghate, Manjunath
Kulkarni, Manohar V
Keywords: Bromomethylcoumarins
diacetyl resorcinol
aldol condensation
anti-inflammatory activity
Issue Date: Aug-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 311/00 // A 61 P 29/00</b>
Abstract: Various 4-bromomethylcoumarins <b>1</b> have been reacted with diacetyl resorcinol <b>2</b> to afford corresponding ethers <b>3</b>, which undergo intermolecular aldol condensation followed by dehydration to form 4-(5'-acetyl-6'-hydroxy-3'-methylbenzofuran-2'-yl) coumarin <b>4</b>. Further compound <b style="">4</b> on reaction with sodium acetate and acetic anhydride afford 6-acetyl-3, 7-dimethyl-2-(coumarin 4'-yl) furo [3,2-<i style="">g</i>] chromen-5-one <b>5</b>. Their structures have been confirmed by IR, NMR and mass spectral data. Of these compounds, <b style="">4e</b>, <b style="">4f</b> and <b style="">5e</b> show good anti-inflammatory and analgesic activity.
Description: 1674-1678
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(08) [August 2005]

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