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IJC-B Vol.44B(08) [August 2005] >

Title: Synthesis and anti-inflammatory activity of 4-(5'-acetyl-6'-hydroxy -3'-methyl-benzofuran-2'-yl) coumarin and 6-acetyl-3, 7-dimethyl-2-(coumarin-4'-yl) furo [3,2-g] chromen-5-one
Authors: Ghate, Manjunath
Kulkarni, Manohar V
Keywords: Bromomethylcoumarins
diacetyl resorcinol
aldol condensation
anti-inflammatory activity
Issue Date: Aug-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D 311/00 // A 61 P 29/00
Abstract: Various 4-bromomethylcoumarins 1 have been reacted with diacetyl resorcinol 2 to afford corresponding ethers 3, which undergo intermolecular aldol condensation followed by dehydration to form 4-(5'-acetyl-6'-hydroxy-3'-methylbenzofuran-2'-yl) coumarin 4. Further compound 4 on reaction with sodium acetate and acetic anhydride afford 6-acetyl-3, 7-dimethyl-2-(coumarin 4'-yl) furo [3,2-g] chromen-5-one 5. Their structures have been confirmed by IR, NMR and mass spectral data. Of these compounds, 4e, 4f and 5e show good anti-inflammatory and analgesic activity.
Page(s): 1674-1678
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(08) [August 2005]

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