Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9152
Title: Chemoselective reaction of indole 1,3-dicarboxylates towards hydrazine hydrate: Bisheterocycles: Synthesis and antimicrobial activity of some new 2-methyl-3-ethoxycarbonyl-1-oxadiazolyl/thiazolidinonyl/pyrrolyl­aminocarbonylmethylindoles
Authors: Bhovi, Manjunath G
Gadaginamath, Guru S
Keywords: Thioglycolic acid
indole dicarboxylates
antibacterial activity
antifungal activity
Issue Date: Aug-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 209/04</b>
Abstract: Chemoselectivity of 1-ester over C<sub>3</sub>-ester of the indole dicarboxylates <b style="">3a,b</b> towards the nucleophilic attack of hydrazine hydrate has been evidenced by the exclusive formation of 1-hydrazinocarbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles <b style="">5a,b</b> which have been further reacted separately with CS<sub>2</sub>/KOH, <i>p</i>-chlorobenzaldehyde and acetonyl acetone to furnish the 1-(5-mercapto-1,3,4-oxadiazol-2-yl)methyl-3-ethoxycarbonyl-5-substituted-2-methylindoles <b style="">6a,b</b>, 1-<i>p</i>-Chlorobenzyl­idene­hydrazinocarbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles <b style="">7a,b</b> and 1-(2,5-dimethyl­pyrrol-1-yl)­amino­carbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles <b style="">8a,b</b> respectively. The Schiff’s bases <b style="">7a,b</b> are reacted separately with thioglycolic acid to get the desired 1-(2-<i>p</i>-chlorophenyl-4-thiazolidinon-1-yl)aminocarbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles <b style="">9a,b</b>. These newly synthesised compounds are screened for their antibacterial and antifungal activities.
Description: 1663-1668
URI: http://hdl.handle.net/123456789/9152
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(08) [August 2005]

Files in This Item:
File Description SizeFormat 
IJCB 44B(8) 1663-1668.pdf67.06 kBAdobe PDFView/Open


Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.