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IJC-B Vol.44B(08) [August 2005] >

Title: Chemoselective reaction of indole 1,3-dicarboxylates towards hydrazine hydrate: Bisheterocycles: Synthesis and antimicrobial activity of some new 2-methyl-3-ethoxycarbonyl-1-oxadiazolyl/thiazolidinonyl/pyrrolyl­aminocarbonylmethylindoles
Authors: Bhovi, Manjunath G
Gadaginamath, Guru S
Keywords: Thioglycolic acid
indole dicarboxylates
antibacterial activity
antifungal activity
Issue Date: Aug-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D 209/04
Abstract: Chemoselectivity of 1-ester over C3-ester of the indole dicarboxylates 3a,b towards the nucleophilic attack of hydrazine hydrate has been evidenced by the exclusive formation of 1-hydrazinocarbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles 5a,b which have been further reacted separately with CS2/KOH, p-chlorobenzaldehyde and acetonyl acetone to furnish the 1-(5-mercapto-1,3,4-oxadiazol-2-yl)methyl-3-ethoxycarbonyl-5-substituted-2-methylindoles 6a,b, 1-p-Chlorobenzyl­idene­hydrazinocarbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles 7a,b and 1-(2,5-dimethyl­pyrrol-1-yl)­amino­carbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles 8a,b respectively. The Schiff’s bases 7a,b are reacted separately with thioglycolic acid to get the desired 1-(2-p-chlorophenyl-4-thiazolidinon-1-yl)aminocarbonylmethyl-3-ethoxycarbonyl-5-substituted-2-methylindoles 9a,b. These newly synthesised compounds are screened for their antibacterial and antifungal activities.
Page(s): 1663-1668
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(08) [August 2005]

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