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Title: Synthesis of potential fungicidal bibenzyls from bio-renewable source
Authors: Siddiqui, Ibadur R
Singh, Jaya
Singh, Pravin K
Singh, Jagdamba
Keywords: Bibenzyls
aryl amines
Schiff’s bases
neucleophilic addition
2-mercaptopropionic acid
microwave irradiation
antifungal screening
Issue Date: Jul-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 C 15/00 // A 61 P</b>
Abstract: Acetylation of bibenzyl <b style="">1</b> yields 4,4<i style="">'</i>-diacetylbibenzyl <b style="">2</b>, which on condensation with different aryl amines gives corresponding Schiff’s bases <i style="">in situ. </i>Nucleophilic addition of 2-mercaptopropionic acid or 2-mercaptosuccinic acid on Schiff’s bases followed by cyclodehydration in solvent-free condition under microwave irradiation affords 4,4<i style="">'</i>-bis(3<i style="">"</i>-aryl-2<i style="">"</i>-methyl-5<i style="">"</i>-methyl/carboxymethyl-4<i style="">"</i>-oxo-thiazolidin-2<i style="">"</i>-yl)bibenzyl <b style="">3a-n</b> with excellent yield (88-94%). The rate of the reaction is enhanced 225 times in comparison with conventional method.<i style=""> </i>Antifungal screening results on <i style="">Fusarium oxysporum </i>and <i style="">Penicillium citrinum</i> show that most of the synthesized compounds display promising antifungal activity, comparable with Griseofulvin and Dithane M-45 as standards.
Description: 1460-1464
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(07) [July 2005]

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