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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(07) [July 2005] >
| Title: | Synthesis of 2-(amino acid ester)-6-(1,1-dimethylethyl)-3-cyclohexyl-2H-3,4-dihydro-1,3,2-benzoxazaphosphorin 2-sulfides/oxides |
| Authors: | Reddy, P Vasu Govardhana
Haranath, P
Reddy, C Suresh
Raju, C Naga |
| Keywords: | 1,3,2-Benzoxazaphosphorin-2 sulphides/oxides
amino acid methyl ester hydrochlorides
tetrahydrofuran
triethylamine |
| Issue Date: | Jul-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D |
| Abstract: | Synthesis of 2-(amino acid
ester)-6-(1,1-dimethylethyl)-3-cyclohexyl-2H-3,4-dihydro-1,3,2-benzoxazaphosphorin
2-sulfides/oxides 4a-j are
accomplished through a two step process. It involves the prior preparation of
the monochloride as 2-chloro-6-(1,1-dimethylethyl)-3-cyclohexyl-3,4-dihydro-2H-1,3,2-benzoxazaphosphorin
2-sulfide/oxide 3a/3b and their
subsequent reaction with the amino acid methyl ester hydrochlorides 1a-e in dry tetrahydrofuran in the
presence of triethylamine at various temperatures. They are characterized by
IR, 1H, 13C, 31P NMR and mass spectral data. |
| Page(s): | 1437-1440 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(07) [July 2005]
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