Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9146
Title: Synthesis of 2-(amino acid ester)-6-(1,1-dimethylethyl)-3-cyclohexyl-2<i style="">H</i>-3,4-dihydro-1,3,2-benzoxazaphosphorin 2-sulfides/oxides
Authors: Reddy, P Vasu Govardhana
Haranath, P
Reddy, C Suresh
Raju, C Naga
Keywords: 1,3,2-Benzoxazaphosphorin-2 sulphides/oxides
amino acid methyl ester hydrochlorides
tetrahydrofuran
triethylamine
Issue Date: Jul-2005
Publisher: CSIR
Series/Report no.: <b>Int.Cl.<sup>7</sup> C 07 D</b>
Abstract: Synthesis of 2-(amino acid ester)-6-(1,1-dimethylethyl)-3-cyclohexyl-2<i style="">H</i>-3,4-dihydro-1,3,2-benzoxazaphosphorin 2-sulfides/oxides <b style="">4a-j</b> are accomplished through a two step process. It involves the prior preparation of the monochloride as 2-chloro-6-(1,1-dimethylethyl)-3-cyclohexyl-3,4-dihydro-2<i style="">H</i>-1,3,2-benzoxazaphosphorin 2-sulfide/oxide <b style="">3a/3b</b> and their subsequent reaction with the amino acid methyl ester hydrochlorides <b style="">1a-e</b> in dry tetrahydrofuran in the presence of triethylamine at various temperatures. They are characterized by IR, <sup>1</sup>H, <sup>13</sup>C, <sup>31</sup>P NMR and mass spectral data.
Description: 1437-1440
URI: http://hdl.handle.net/123456789/9146
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(07) [July 2005]

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