24-May-2013
00:48:22 IST
|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(07) [July 2005] >
| Title: | Synthesis of novel angularly fused pentacyclic heterocycles of pharmacological interest |
| Authors: | Padmashali, Basavaraj
Vaidya, V P
Mahadevan, K M
Latha, K P |
| Keywords: | Pentacyclic heterocycles
pyrimidines
phosphorus oxychloride
neucleophilic substitution reaction
hydrazine hydrate
furan derivatives
antimicrobial activity
anthelmintic activity
anticonvulsant activity
antipyretic activity |
| Issue Date: | Jul-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D // A 61 P 31/04, 3110, 25/08, 33/10, 29/00 |
| Abstract: | 2-Substituted-4-oxo-naphtho[2,1-b]furo[3,2-d]pyrimidines 1a-c on
refluxing with phosphorous oxychloride result in the formation of 2-substituted-4-chloronaphtho[2,1-b]furo[3,2-d]pyrimidines 2a-c,
which on nucleophilic substitution reaction with hydrazine hydrate in ethanol
give the required 2-substituted-4-hydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 3a-c. The compounds 3a-c are converted into novel angularly
fused pentacyclic heterocycles viz. tetrazolo[1,5-c]pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 4a-c and triazolo[4,3-c]pyrimido[5,4-b]naphtho[2,1-b]furan derivatives 5a-i
by reacting with appropriate reagents. Condensation of 3a-c with typical aldehydes afford a series of 4-arylidinehydrazinonaphtho[2,1-b]furo[3,2-d]pyrimidines 6a-o. All
the newly synthesized compounds have been characterized by elemental analysis
and spectroscopic data and have been evaluated for antimicrobial, anthelmintic,
anticonvulsant and antipyretic activities. |
| Page(s): | 1446-1451 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(07) [July 2005]
|
|
