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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(07) [July 2005] >
| Title: | Synthesis of pyrazole imines and azetidinone compounds using conventional and microwave technique and studies of their antibacterial activity |
| Authors: | Mistry, Ketan
Desai, K R |
| Keywords: | Pyrozole imines
azetidinone
pyrazoles
chloroacetyl chloride
2-aminobenzothiazole
pyrazolone
microwave methods
antibacterial activity |
| Issue Date: | Jul-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 277/02 |
| Abstract: | A series of compounds 4-[spiro-{1′-(4′′-methylphenyl)-3′-methyl}-pyrazole]-3-chloro-1-(substitutedbenzothiazole)-2-azetidinone
4a-j have been prepared by the
reaction of 1-(4′-methylphenyl)-3-methyl-5-(2′′-iminosubstitutedbenzothiazole)pyrazoles
3a-j with chloroacetyl chloride in
the presence of triethylamine. The pyrazole derivatives 3a-j have been prepared by the condensation of substituted
2-aminobenzothiazole 1 with
1-(4′-methylphenyl)-3-methyl-5-pyrazolone 2.
Both the reactions have been carried out by conventional and microwave methods.
The synthesized compounds are screened for their antibacterial activity against
Staphylococcus aureus, Bacillus subtilis,
Escherichia coli and Salmonella
typhi. |
| Page(s): | 1452-1455 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(07) [July 2005]
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