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IJC-B Vol.44B(07) [July 2005] >


Title: Synthesis of pyrazole imines and azetidinone compounds using conventional and microwave technique and studies of their antibacterial activity
Authors: Mistry, Ketan
Desai, K R
Keywords: Pyrozole imines
azetidinone
pyrazoles
chloroacetyl chloride
2-aminobenzothiazole
pyrazolone
microwave methods
antibacterial activity
Issue Date: Jul-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D 277/02
Abstract: A series of compounds 4-[spiro-{1′-(4′′-methylphenyl)-3′-methyl}-pyrazole]-3-chloro-1-(substitutedbenzothiazole)-2-azetidinone 4a-j have been prepared by the reaction of 1-(4′-methylphenyl)-3-methyl-5-(2′′-imino­substituted­benzo­thiazole)pyrazoles 3a-j with chloroacetyl chloride in the presence of triethylamine. The pyrazole derivatives 3a-j have been prepared by the condensation of substituted 2-aminobenzothiazole 1 with 1-(4′-methylphenyl)-3-methyl-5-pyrazolone 2. Both the reactions have been carried out by conventional and microwave methods. The synthesized compounds are screened for their antibacterial activity against Staphylococcus aureus, Bacillus subtilis, Escherichia coli and Salmonella typhi.
Page(s): 1452-1455
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(07) [July 2005]

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