Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9124
Title: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="State"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> Amidation<b> </b>of amines with esters catalyzed<b> </b>by <i>Candida antarctica</i><b> </b>lipase (CAL) </smarttagtype></smarttagtype>
Authors: Yang, Bo
Zhang, Yanjun
Zhang, Shusheng
Izumi, T
Issue Date: Jun-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 C 211/01</b>
Abstract: <smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="State"><smarttagtype namespaceuri="urn:schemas-microsoft-com:office:smarttags" name="place"> <i style="">Candida antarctica </i>lipase (CAL) is used to convert amines and esters into amides<b>, </b>especially as a chiral resoluting catalyst for the enantioselective amidation of racemic esters or racemic amines in an effort to demonstrate the ability of lipase to differentiate between enantiomeric substrates. It is a very useful synthetic method for amides. The effects of substrate modification on the yield and enantiomeric excess (<i>ee</i>) are studied. The <i>R-</i>enantiomer will react faster for racemic mixture of amine in which the amino group attaches directly to the chiral carbon, and the same for racemic mixture of ester in which the carbonyl group attaches directly to the chiral carbon. The enantioselectivity of CAL is complicated for the amidation of racemic mixture of amine with racemic mixture of ester.  </smarttagtype></smarttagtype>
Description: 1312-1316
URI: http://hdl.handle.net/123456789/9124
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(06) [June 2005]

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