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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(06) [June 2005] >
| Title: | Bismuth oxide perchlorate catalysed efficient synthesis of 3,4-dihydropyrimidin-2(1H)-ones: An improved high yielding protocol for the Biginelli reaction |
| Authors: | Reddy, Y Thirupathi
Reddy, P Narsimha
Kumar, B Sunil
Rao, G V P
Rajitha, B |
| Issue Date: | Jun-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 239/00 |
| Abstract: | Dihydropyrimidines are
prepared by a one-pot cyclocondensation of aldehydes, β-ketoesters and urea
in acetonitrile by using bismuth oxide perchlorate as the catalyst for the
first time is described. Compared to the classical Biginelli reaction
conditions, this new method consistently has the advantage of excellent yields
(85-95%) and short reaction time (2-4 hr) at lower temperature (40-50oC). |
| Page(s): | 1304-1306 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(06) [June 2005]
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