NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(06) [June 2005] >

Title: Polymorphic study of donepezil hydrobromide
Authors: Elati, Chandrashekar R
Vankawala, Pravinchandra J
Chalamala, Subrahmanyeswara Rao
Kolla, Naveenkumar
Gangula, Srinivas
Vurimidi, Himabindu
Sundaram, Venkataraman
Mathad, Vijayavitthal T
Issue Date: Jun-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D
Abstract: Six polymorphs of donepezil hydrobromide 1, having unique physical properties have been identified and characterized by various thermal, spectroscopic and powder X-Ray diffraction techniques. During our extensive research on screening the pharmaceutically acceptable salts and polymorphic forms of donepezil, we encountered various polymorphic changes in hydrobromide salt of donepezil in different solvents, temperature, and time conditions. The systematic study led us to prepare six polymorphs and these are characterized by using different analytical techniques such as, powder X-Ray diffraction (PXRD), Differential scanning calorimetry (DSC), Thermogravimetric analysis (TGA), IR spectroscopy and Karl Fischer techniques. Different methods for the synthesis of each polymorph and characterization of these novel polymorphs have been discussed.
Page(s): 1231-1235
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(06) [June 2005]

Files in This Item:

File Description SizeFormat
IJCB 44B(6) 1231-1235.pdf191.08 kBAdobe PDFView/Open
 Current Page Visits: 853 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 165783 since 01-Sep-2015  Last updated on 27-Jun-2016Webmaster: