Please use this identifier to cite or link to this item:
Title: Theoretical study on the mechanism of alkylation at N-7 of guanine by few nitrogen mustards
Authors: Bhattacharyya, P K
Medhi, C
Issue Date: Jun-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D 473/18
Abstract: The interaction of aziridinium ion with N-7 of guanine is considered the common reaction step in the alkylation of DNA by nitrogen mustards. However, the involvement of another inter­mediate, carbonium ion is expected in some nitrogen mustards. The study on the energies of forming these inter­mediates indicates that carbonium ion is generated at different energy levels in the transition state and energetically less favourable, which might indirectly explain the experimentally observed lower alkylating abilities of some nitrogen mustards. These drugs acquire ability of generating aziridinium ion but substitution at N-4 might not enhance the reactivity of nitrogen mustards. Some drugs may generate another energetically less favourable carbonium ion intermediate.
Page(s): 1319-1323
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(06) [June 2005]

Files in This Item:
File Description SizeFormat 
IJCB 44B(6) 1319-1323.pdf52.2 kBAdobe PDFView/Open

Items in NOPR are protected by copyright, with all rights reserved, unless otherwise indicated.