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Title: A novel and short convergent approach for N-aryl-5-aminomethyl-2-oxazolidinone derivatives Linezolid and DUP-721
Authors: Madhusudhan, G
Reddy, G Om
Ramanatham, J
Dubey, P K
Issue Date: Jun-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D
Abstract: A new convergent and short approach for oxazolidinone class of antibacterial agents, Linezolid and DUP-721, has been achieved by condensing 3-chloro-2-((phenoxycarbonyl)oxy) propyl azide with aryl amine followed by reductive acetylation. This one pot approach for N-aryl-5-azidomethyl- 2-oxazolidinone could provide access for rapid preparation of various oxazolidinone analogues.
Page(s): 1236-1238
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(06) [June 2005]

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