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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(05) [May 2005] >
| Title: | 1,3-Dipolar cycloaddition reactions: Synthesis and antimicrobial activity of novel 1-triazolylethylindole and 1-triazolylethylbenz[g]indole derivatives |
| Authors: | Bhovi, Manjunath G
Gadaginamath, Guru S |
| Issue Date: | May-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 209/04 |
| Abstract: | Indole azide 4 and benz[g]indole azide 12
are reacted separately with dimethyl acetylenedicarboxylate to secure the
desired
1-[4,5-dimethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole
5 and 1-[4,5-dimethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole
13, respectively. The reaction of
indole azide 4 and benz[g]indole
azide 12 with ethyl propiolate has
been found to be regiospecific and produce only the
1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole
6 and
1-[4-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylbenz[g]indole
14, respectively. Indole azide 4 is also reacted with ethyl
phenylpropolate to secure two isomeric products
1-[4-ethoxycarbonyl-5-phenyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole
8 and
1-[4-phenyl-5-ethoxycarbonyl-1,2,3-triazol-1-yl]ethyl-3-ethoxycarbonyl-5-methoxy-2-methylindole
9. All these newly synthesised
compounds are screened for their antimicrobial activities. |
| Page(s): | 1068-1073 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(05) [May 2005]
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