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Title: Cyclodehydration reaction in water medium leads to library/multigram synthesis of 1,5-diarylpyrazoles
Authors: Singh, Sunil K
Saibaba, V
Rao, Y Koteswar
Issue Date: May-2005
Publisher: CSIR
Series/Report no.: Int.Cl.7 C 07 D 207/00
Abstract: The cyclodehydration reaction leading to 1,5-diarylpyrazoles in water medium has been observed for the first time. The method has been used in generating library of compounds for drug discovery program under microwave condition and tried for a multigram synthesis of celecoxib, a premier COX-2 inhibitor, under normal laboratory condition.
Description: 1115-1118
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(05) [May 2005]

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