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|Title:||Synthesis and antimicrobial screening of N-[coumarin-6-ylamino]thiazolidinone and spiro indolo-thiazolidinone derivatives|
|Authors:||Choudhari, B P|
Mulwad, V V
|IPC Code:||Int.Cl.7 C 07 D 209/04 // A 61 P 31/04, 31/10|
|Abstract:||Condensation of N-[coumarin-6-yl]hydrazonoarylmethanes 3a-h obtained from the condensation of the coumarin-6-ylhydrazine hydrochloride 2a-d and aromatic aldehydes, on treatment with mercaptoacetic acid in dry 1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride yields N-[coumarin-6-ylamino]-2-arylthiazolidin-4(H)-ones 4a-h. While, coumarin-6-ylhydrazine hydrochloride 2a-d on condensation with isatin in situ yields corresponding 1,2-dihydro-3-[coumarin-6-ylhydrazono]indol-2-ones 5a-d. Compound 5a-d on treatment with mercaptoacetic acid in dry 1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride affords N-[coumarin-6-ylamino]spiro-[3H-indole-(1H,2H)-3,2-(4H)-thiazolidine]-2,4-diones 6a-d. The structures of the compounds 3, 4, and 6 have been confirmed on the basis of their spectral and analytical data. The above compounds are screened for their antimicrobial activities and have been found to exhibit significant antibacterial and antifungal activities.|
|Appears in Collections:||IJC-B Vol.44B(05) [May 2005]|
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