Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9092
Title: Synthesis and antimicrobial screening of N-[coumarin-6-ylamino]thiazolidinone and spiro indolo-thiazolidinone derivatives
Authors: Choudhari, B P
Mulwad, V V
Issue Date: May-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 209/04 // A 61 P 31/04, 31/10</b>
Abstract: Condensation of N-[coumarin-6-yl]hydrazonoarylmethanes <b style="">3a-h</b> obtained from the condensation of the coumarin-6-ylhydrazine hydrochloride <b>2a-d</b> and aromatic aldehydes, on treatment with mercaptoacetic acid in dry 1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride yields N-[coumarin-6-ylamino]-2-arylthiazolidin-4(<i>H</i>)-ones <b style="">4a-h</b>. While, coumarin-6-ylhydrazine hydrochloride <b style="">2a-d</b> on condensation with isatin <i>in situ</i> yields corresponding 1,2-dihydro-3-[coumarin-6-ylhydrazono]indol-2-ones <b style="">5a-d</b>. Compound <b>5a-d</b> on treatment with mercaptoacetic acid in dry 1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride affords N-[coumarin-6-ylamino]spiro-[3<i style="">H</i>-indole-(1<i>H</i>,2<i>H</i>)-3,2-(4<i>H</i>)-thiazolidine]-2,4-diones <b style="">6a-d</b>. The structures of the compounds <b>3</b>, <b>4</b>, and <b>6</b> have been confirmed on the basis of their spectral and analytical data. The above compounds are screened for their antimicrobial activities and have been found to exhibit significant antibacterial and antifungal activities.
Description: 1074-1078
URI: http://hdl.handle.net/123456789/9092
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(05) [May 2005]

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