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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(05) [May 2005] >
| Title: | Synthesis and antimicrobial screening of N-[coumarin-6-ylamino]thiazolidinone and spiro indolo-thiazolidinone derivatives |
| Authors: | Choudhari, B P
Mulwad, V V |
| Issue Date: | May-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 209/04 // A 61 P 31/04, 31/10 |
| Abstract: | Condensation of
N-[coumarin-6-yl]hydrazonoarylmethanes 3a-h
obtained from the condensation of the coumarin-6-ylhydrazine hydrochloride 2a-d
and aromatic aldehydes, on treatment with mercaptoacetic acid in dry
1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride
yields N-[coumarin-6-ylamino]-2-arylthiazolidin-4(H)-ones 4a-h. While, coumarin-6-ylhydrazine
hydrochloride 2a-d on condensation
with isatin in situ yields corresponding
1,2-dihydro-3-[coumarin-6-ylhydrazono]indol-2-ones 5a-d. Compound 5a-d on treatment with mercaptoacetic acid in
dry 1,4-dioxane in the presence of catalytic amount of anhydrous zinc chloride
affords N-[coumarin-6-ylamino]spiro-[3H-indole-(1H,2H)-3,2-(4H)-thiazolidine]-2,4-diones
6a-d. The structures of the
compounds 3, 4, and 6 have been confirmed on the basis of
their spectral and analytical data. The above compounds are screened for their
antimicrobial activities and have been found to exhibit significant
antibacterial and antifungal activities. |
| Page(s): | 1074-1078 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(05) [May 2005]
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