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Title: 2,4,5-Trichlorophenyl-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)methylcarbamates: Synthesis, isolation, characterization and utility in the synthesis of dipeptidyl ureas
Authors: Babu, Vommina V Suresh
Issue Date: May-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 K</b>
Abstract: An efficient synthesis of 2,4,5-trichlorophenyl-(9<i>H</i>-fluoren-9-ylmethoxycarbonylamino)methylcarbamates employing isocyanates derived from several Fmoc-amino acids has been described. All the carbamates made have been obtained as crystalline solids and are fully characterized by IR, <sup>1</sup>H NMR, <sup>13</sup>C NMR and mass spectrometry. They have been used as building blocks for the synthesis of several dipeptidyl urea esters. The coupling of carbamates with <i>N,O</i>-bis[trimethyl¬≠silyl]amino acids resulted in Fmoc-protected dipeptide urea acids in good yield as well as purity. All the dipeptidyl urea esters and acids made have been well characterized.
Description: 1046-1053
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(05) [May 2005]

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