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Title: 2,4,5-Trichlorophenyl-(9H-fluoren-9-ylmethoxycarbonylamino)methylcarbamates: Synthesis, isolation, characterization and utility in the synthesis of dipeptidyl ureas
Authors: Babu, Vommina V Suresh
Issue Date: May-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 K
Abstract: An efficient synthesis of 2,4,5-trichlorophenyl-(9H-fluoren-9-ylmethoxycarbonylamino)methylcarbamates employing isocyanates derived from several Fmoc-amino acids has been described. All the carbamates made have been obtained as crystalline solids and are fully characterized by IR, 1H NMR, 13C NMR and mass spectrometry. They have been used as building blocks for the synthesis of several dipeptidyl urea esters. The coupling of carbamates with N,O-bis[trimethyl¬≠silyl]amino acids resulted in Fmoc-protected dipeptide urea acids in good yield as well as purity. All the dipeptidyl urea esters and acids made have been well characterized.
Page(s): 1046-1053
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(05) [May 2005]

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