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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(06) [June 2010] >
| Title: | Small-sized neurons of trigeminal ganglia express multiple voltage-sensitive calcium channels: A qualitative immunohistochemical study |
| Authors: | Ray, Subrata Basu
Singh, Sagolshem S
Mehra, R D |
| Keywords: | Calcium
Ganglia
Immunohistochemistry
Ion channel
Rat
Trigeminal |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| Abstract: | The cell bodies of pseudounipolar neurons of
the trigeminal ganglia have been presumed to play a supportive role to
neurites, which transmit various sensations like pain from the periphery to the
brain stem. However, several studies have recently shown that these neuronal
cell bodies could modulate the afferent stimuli by up-regulating various ion
channels and also by increasing the synthesis of neuropeptides like calcitonin
gene-related peptide (CGRP). Since voltage-sensitive calcium ion channels
(VSCCs) determine neuropeptides/ neurotransmitters released by neurons, the aim
of the present
study was to localize the various VSCCs (N-, P/Q-, L-, T- and R-types) in the
trigeminal ganglia neurons by immunohistochemistry. The results showed that all
the VSCCs are expressed by the cell bodies of neurons though the small-sized
neurons showed higher expression of these channels. The small-sized neurons
were identified by immunohistochemical localization of CGRP, the most common
neuropeptide for pain transmission in the trigeminal ganglia neurons. Some of
these channels (N, P/Q and T types) were also expressed on the cell surface
though previous electrophysiological studies have shown the expression of all
the channels on the cell surface. It is suggested that the cell bodies could
play a more active role than hereto ascribed to these, in the modulation of
sensory stimuli. |
| Page(s): | 538-543 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(06) [June 2010]
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