|
NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(06) [June 2010] >
| Title: | Effect of preferential cyclooxygenase-2 (COX-2) inhibitor against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced striatal lesions in rats: Behavioral, biochemical and histological evidences |
| Authors: | Gupta, Amit
Dhir, Ashish
Kumar, Anil
Kulkarni, S K |
| Keywords: | Cyclooxygenase
1-methyl-4-phenyl-1,2,3,6-tertahydropyridine
Nimesulide
Neuroprotection
Oxidative stress
Parkinson’s disease |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| Abstract: | Cyclooxygenase (COX) isoenzyme is known to
play an important role in the pathophysiology of Parkinson’s disease. The
present study evaluated the neuroprotective effect of nimesulide, a
preferential COX-2-inhibitor against
1-methyl-4-phenyl-1,2,3,6-tertahydropyridine (MPTP)-model of Parkinson’s
disease. Intrastriatal administration of MPTP (32 μmol in 2 μl) produced a
significant decrease in the locomotor activity. Biochemical investigation of
striatal region revealed a significant enhancement in the oxidative stress as
evidenced by increased lipid peroxidation levels, nitrite levels and myeloperoxidase
activity along with depleted antioxidant pool (reduced glutathione and
superoxide dismutase levels) and reduced redox (GSH/GSSG) ratio. MPTP
administration also showed significant mitochondrial complex-I inhibition and
reduction in the mitochondrial viability. Histological examination of the
MPTP-treated brain sections revealed alteration in the histo-architecture as
well as undifferentiated bodies of varying contour and lesions. Chronic
administration of nimesulide (5 or 10 mg/kg, po) for 12 days, significantly
reversed the behavioral, biochemical, mitochondrial and histological
alterations induced by MPTP. In conclusion, the findings of the present study
implicate the possible neuroprotective potential of nimesulide in MPTP-treated
rats and thus highlight the therapeutic potential of COX-inhibitors in
treatment of Parkinson’s disease. |
| Page(s): | 577-585 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(06) [June 2010]
|
|
