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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(06) [June 2010] >
| Title: | Effect of Ocimum sanctum, turmeric extract and vitamin E supplementation on the salivary gland and bone marrow of radioiodine exposed mice |
| Authors: | Bhartiya, Uma S
Joseph, Lebana J
Raut, Yogita S
Rao, Badanidiyoor S |
| Keywords: | Antioxidants
Bone marrow
Radioiodine
Salivary glands |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| Abstract: | Significant increase in the salivary gland
weight was observed after exposure to single therapeutic dose of 3.7 MBq
of 131I in mice. Pre-supplementation of antioxidants, O. sanctum
leaf extract, turmeric extract and vitamin E for 15 days before 131I
exposure demonstrated significant reduction in the salivary gland weight. No
major histopathological changes were observed in the salivary gland of
experimental animals at 24 h of exposure. Micronuclei index in the bone marrow
of polychromatic (PCEs) and normochromatic erythrocytes (NCEs) remained
unchanged in all the experimental groups. However, PCE/NCE ratio in the bone
marrow decreased significantly in all the 131I exposed animals
irrespective of antioxidant supplementation status. The normalization of
salivary gland weight by antioxidant pre-supplementation in radioiodine exposed
mice is suggestive of the possible ameliorating effect of antioxidants on the
salivary gland weight recommending further detailed studies regarding the
functional aspect of the salivary gland in higher animals. |
| Page(s): | 566-571 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(06) [June 2010]
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