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Indian Journal of Experimental Biology (IJEB) >
IJEB Vol.48 [2010] >
IJEB Vol.48(06) [June 2010] >
| Title: | Thyroxine induced stress and its possible prevention by catechin |
| Authors: | Chandra, Amar K
Sinha, Sabyasachi
Choudhury, Shyamosree Roy |
| Keywords: | Antioxidants
Catalase
Catechin
Free radical
Lipid peroxidation
Oxidative stress
Superoxide dismutase
Thyroxine |
| Issue Date: | Jun-2010 |
| Publisher: | CSIR |
| Abstract: | Free radicals are all known to damage cell
components. The present study was designed to evaluate the free radical
generation in the testis and liver and also to determine the testicular and hepatic antioxidant enzyme
activities with and without catechin administration in thyroxine induced male Sprague-Dawley rats. The experimental animals were divided into four
groups, six on each division. L-thyroxine
(T4) (0.3 mg/kg body weight) was administered to experimental groups
for 15 days. Another group (CAT-T4) was administered with L-thyroxine
(T4) in the dose as mentioned and catechin (100mg/kg of body
weight/day) simultaneously. Third group was administered only with catechin,
and the remaining group was kept as control. Lipid peroxidation level (LPO)
increased in L-thyroxine treated rats as compared to control, while LPO level
was almost normal in L-thyroxine (T4) and
catechin (CAT-T4) treated group. Superoxide dismutase (SOD) and
catalase activities were increased in L-thyroxine (T4) treated rats
as compared to control, where as there were almost at normal level in L-thyroxine
(T4) and catechin (CAT-T4) treated groups. The results
show that, thyroxine administration develops oxidative stress; the organism
defends it against the effects of oxidative stress by increasing SOD and catalase
activities as a protective mechanism and catechin, being an antioxidant,
normalizes lipid peroxidation in testis and liver including SOD and catalase activities. |
| Page(s): | 559-565 |
| ISSN: | 0975-1009 (Online); 0019-5189 (Print) |
| Source: | IJEB Vol.48(06) [June 2010]
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