Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/9072
Title: Anti-resorptive<b style=""> </b>effect of pilose antler blood (<i style="">Cervus nippon Temminck</i>) in ovariectomized rats
Authors: Yang, Jian-Hong
Cao, Yi
Wang, Rui-Lin
Fei, Yu-Rong
Zhang, Hui
Feng, Pu
Liu, Jing
Keywords: Bone mineral density
17 <img src='/image/spc_char/beta.gif' border=0>-estradiol
Insulin-like growth factor-1
Osteoporosis
Pilose antler blood
Testosterone
Issue Date: Jun-2010
Publisher: CSIR
Abstract: Anti-bone resorption activity of pilose antler blood (<i style="">Cervus nippon Temminck</i>) were evaluated in ovariectomized Wistar rats. The rats were randomly divided into sham operated group (SHAM), ovariectomized group (OVX) and pilose antler blood treated group. The ovariectomized rats were treated with pilose antler blood orally in 4000<img src='/image/spc_char/micro.gif' border=0>l/kg daily doses for 10 weeks. Compared with SHAM group, serum 17 <img src='/image/spc_char/beta.gif' border=0>-estradiol level decreased significantly and osteocalcin level increased significantly in OVX group, indicating successful model of osteoporosis. The experiments showed that the bone mineral density of the lumbar spine and left femur in OVX group decreased remarkably compared to SHAM group but normalized by treatment with pilose antler blood. Additionally, serum levels of insulin-like growth factor-1and testosterone were lower obviously in OVX group than those in SHAM group but preserved by pilose antler blood treatment. However, no obvious changes in serum levels of calcium, phosphorus, total alkaline phosphatase and osteoprotegerin were observed among three groups. These results suggested that administration of pilose antler blood was effective in alleviating osteoporosis in ovariectomized rats.<b style=""><i style=""></i></b>
Description: 554-548
URI: http://hdl.handle.net/123456789/9072
ISSN: 0975-1009 (Online); 0019-5189 (Print)
Appears in Collections:IJEB Vol.48(06) [June 2010]

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