NISCAIR Online Periodicals Repository

Research Journals >
Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.17 [2010] >
IJCT Vol.17(3) [May 2010] >

Title: Simultaneous spectrophotometric estimation and validation of three component tablet formulation containing paracetamol, nimesulide and tizanidine
Authors: Chandratrey, A
Sharma, R
Keywords: Derivative spectrophotometry
Issue Date: May-2010
Publisher: CSIR
Abstract: In the present study, two spectrophotometric methods that do not require prior separation for simultaneous estimation of three drugs: paracetamol, nimesulide, and tizanidine in tablet formulation have been reported. Shimadzu UV-1700, capable of multi-component analysis was used for quantitation. Method I was based on derivative spectrophotometry and the absorbances were measured at 229.5, 271, and 323.0 nm, being the zero crossing points for paracetamol, nimesulide and tizanidine, respectively. Method II is based on multi-wavelength spectroscopic method, absorbances of standard solutions were measured at 229.0 nm, 272.0 nm, 262.0 nm and 323.0 nm based on statistical calculations and results of the sample solutions. All the three drugs obey Beer’s law in the concentration range employed for the methods. The results of the analysis for both methods were tested and validated for various parameters according to International Conference on Harmonization Q 2B guidelines. The utility of the developed methods has been demonstrated by analysis of commercially available tablet dosage form.
Page(s): 229-232
ISSN: 0975-0991 (Online); 0971-457X (Print)
Source:IJCT Vol.17(3) [May 2010]

Files in This Item:

File Description SizeFormat
IJCT 17(3) 229-232.pdf100.08 kBAdobe PDFView/Open
 Current Page Visits: 1310 
Recommend this item


Online Submission of Articles |  NISCAIR Website |  National Knowledge Resources Consortium |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2015 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 170165 since 01-Sep-2015  Last updated on 30-Jun-2016Webmaster: