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Research Journals >
Indian Journal of Chemical Technology (IJCT) >
IJCT Vol.17 [2010] >
IJCT Vol.17(3) [May 2010] >
| Title: | Simultaneous spectrophotometric estimation and validation of three component tablet formulation containing paracetamol, nimesulide and tizanidine |
| Authors: | Chandratrey, A
Sharma, R |
| Keywords: | Derivative spectrophotometry
Validation
Paracetamol
Nimuslide
Tizanidine |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: | In the present study, two spectrophotometric
methods that do not require prior separation for simultaneous estimation of
three drugs: paracetamol, nimesulide, and tizanidine in tablet formulation have
been reported. Shimadzu UV-1700, capable of multi-component analysis was used
for quantitation. Method I was based on derivative spectrophotometry and the
absorbances were measured at 229.5, 271, and 323.0 nm, being the zero crossing
points for paracetamol, nimesulide and tizanidine, respectively. Method II is
based on multi-wavelength spectroscopic method, absorbances of standard
solutions were measured at 229.0 nm, 272.0 nm, 262.0 nm and 323.0 nm based on
statistical calculations and results of the sample solutions. All the three
drugs obey Beer’s law in the concentration range employed for the methods. The
results of the analysis for both methods were tested and validated for various
parameters according to International Conference on Harmonization Q 2B
guidelines. The utility of the developed methods has been demonstrated by
analysis of commercially available tablet dosage form. |
| Page(s): | 229-232 |
| ISSN: | 0975-0991 (Online); 0971-457X (Print) |
| Source: | IJCT Vol.17(3) [May 2010]
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