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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(05) [May 2005] >
| Title: | Revised synthesis of the pentasaccharide related to the repeating unit of the O-antigen from Shigella dysenteriae type-4 in the form of its methyl ester 2-(trimethylsilyl)ethyl glycoside |
| Authors: | Sarkar, Sujit Kumar
Mukhopadhyay, Balaram
Roy, Nirmolendu |
| Issue Date: | May-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 H |
| Abstract: | A revised and simplified method has been
developed for the synthesis of the pentasaccharide, related to the repeating
unit of the O-antigen from Shigella dysenteriae type-4. The
disaccharide donor 10 and the trisaccharide acceptor 8 with two
hydroxyl groups are first synthesized which are then allowed to react in the
presence on NIS and TfOH to give a pentasaccharide derivative from which,
removal of protecting groups affords the desired repeating unit, namely
methyl  -L-fucopyranosyl-(1→3)-2-acetamido-2-deoxy--D-glucopyranosyl-(1→3)-2-acetamido-2-deoxy-4-O-( -L-fucopyranosyl)- -D-glucopyranosyl-(1→4)-[2-(trimethylsilyl)ethyl  -D-glucopyranosid] uronate 15. |
| Page(s): | 1058-1063 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(05) [May 2005]
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