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|Title:||Revised synthesis of the pentasaccharide related to the repeating unit of the O-antigen from Shigella dysenteriae type-4 in the form of its methyl ester 2-(trimethylsilyl)ethyl glycoside|
|Authors:||Sarkar, Sujit Kumar|
|Series/Report no.:||Int.Cl.7 C 07 H|
|Abstract:||A revised and simplified method has been developed for the synthesis of the pentasaccharide, related to the repeating unit of the O-antigen from Shigella dysenteriae type-4. The disaccharide donor 10 and the trisaccharide acceptor 8 with two hydroxyl groups are first synthesized which are then allowed to react in the presence on NIS and TfOH to give a pentasaccharide derivative from which, removal of protecting groups affords the desired repeating unit, namely methyl -L-fucopyranosyl-(1→3)-2-acetamido-2-deoxy--D-glucopyranosyl-(1→3)-2-acetamido-2-deoxy-4-O-( -L-fucopyranosyl)- -D-glucopyranosyl-(1→4)-[2-(trimethylsilyl)ethyl -D-glucopyranosid] uronate 15.|
|Appears in Collections:||IJC-B Vol.44B(05) [May 2005]|
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