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IJC-B Vol.44B(04) [April 2005] >


Title: Synthesis of novel naphtho[2,1-b]furo pyrazolyl, isoxazolyl and pyridyl derivatives as potential antimicrobial agents
Authors: Mahadevan, K M
Basavaraj, K M
Mathias, D A Prathima
Vaidya, V P
Issue Date: Apr-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D 231/00, 261/00, 213/00 // A 61 P 31/04, 31/10
Abstract: The treatment of chalcones 2a-f with substituted hydrazines in ethanol results in the formation of 3-(3-aminonaphtho[2,1-b]fur-2-yl)-5-arylpyrazolines 3a-l.The reaction of these chalcones 2a-f  with hydroxylamine hydrochloride in presence of catalytic amount of hydrochloric acid affords 3-(3-aminonaphtho[2,1-b]fur-2-yl)-5-arylisoxazolines 4a-f. The synthesis of another biheterocycle, 2-amino-3-cyano-4-aryl-6-(3-aminonaphtho[2,1-b]fur-2yl)pyridines 5a-f is accomplished by reacting chalcones 2a-f  with malanonitrile in presence of ammonium acetate. All the newly synthesized compounds are characterized by elemental analysis and spectral studies, and evaluated for antimicrobial activity.
Page(s): 789-793
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(04) [April 2005]

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