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http://nopr.niscair.res.in/handle/123456789/9001| Title: | Synthesis of novel naphtho[2,1-b]furo pyrazolyl, isoxazolyl and pyridyl derivatives as potential antimicrobial agents |
| Authors: | Mahadevan, K M Basavaraj, K M Mathias, D A Prathima Vaidya, V P |
| Issue Date: | Apr-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 231/00, 261/00, 213/00 // A 61 P 31/04, 31/10 |
| Abstract: | The treatment of chalcones 2a-f with substituted hydrazines in ethanol results in the formation of 3-(3-aminonaphtho[2,1-b]fur-2-yl)-5-arylpyrazolines 3a-l.The reaction of these chalcones 2a-f with hydroxylamine hydrochloride in presence of catalytic amount of hydrochloric acid affords 3-(3-aminonaphtho[2,1-b]fur-2-yl)-5-arylisoxazolines 4a-f. The synthesis of another biheterocycle, 2-amino-3-cyano-4-aryl-6-(3-aminonaphtho[2,1-b]fur-2yl)pyridines 5a-f is accomplished by reacting chalcones 2a-f with malanonitrile in presence of ammonium acetate. All the newly synthesized compounds are characterized by elemental analysis and spectral studies, and evaluated for antimicrobial activity. |
| Page(s): | 789-793 |
| URI: | http://hdl.handle.net/123456789/9001 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Appears in Collections: | IJC-B Vol.44B(04) [April 2005] |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| IJCB 44B(4) 789-793.pdf | 49.35 kB | Adobe PDF | View/Open |
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