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Title: Chloramine-T mediated synthesis of 1,3,4-oxadiazolyl-1,8-naphthyridines under microwave irradiation
Authors: Mogilaiah, K
Reddy, Ch Srinivas
Issue Date: Apr-2005
Publisher: CSIR
Series/Report no.: Int.Cl.7 C 07 D
Abstract: 1-(5-Aryl-[1,3,4]oxadiazol-2-ylmethyl)-3-(o-chlorophenyl)-1H-[1,8]-naphthyridin-2-ones 5 have been prepared expeditiously by microwave thermolysis of [2-oxo-3-(o-chlorophenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid arylidenehydrazides 4 in the presence of chloramine-T. The intermediate, arylidenehydrazides 4 have been obtained by the condensation of [2-oxo-3-(o-chlorophenyl)-2H-[1,8]naphthyridin-1-yl]acetic acid hydrazide 3 with aromatic aldehydes under microwave irradiation. The products are obtained in good yields with high purity. The characterization of the synthesized compounds has been done by elemental analyses, IR and 1H NMR spectral data.
Description: 768-772
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(04) [April 2005]

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