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Title: Chloramine-T mediated synthesis of 1,3,4-oxadiazolyl-1,8-naphthyridines under microwave irradiation
Authors: Mogilaiah, K
Reddy, Ch Srinivas
Issue Date: Apr-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D</b>
Abstract: 1-(5-Aryl-[1,3,4]oxadiazol-2-ylmethyl)-3-(<i style="">o</i>-chlorophenyl)-1<i style="">H</i>-[1,8]-naphthyridin-2-ones <b style="">5 </b>have been prepared expeditiously by microwave thermolysis of [2-oxo-3-(<i style="">o</i>-chlorophenyl)-2<i style="">H</i>-[1,8]naphthyridin-1-yl]acetic acid arylidenehydrazides <b style="">4</b> in the presence of chloramine-T. The intermediate, arylidenehydrazides <b style="">4</b> have been obtained by the condensation of [2-oxo-3-(<i style="">o</i>-chlorophenyl)-2<i style="">H</i>-[1,8]naphthyridin-1-yl]acetic acid hydrazide <b style="">3</b> with aromatic aldehydes under microwave irradiation. The products are obtained in good yields with high purity. The characterization of the synthesized compounds has been done by elemental analyses, IR and <sup>1</sup>H NMR spectral data.
Description: 768-772
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(04) [April 2005]

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