Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/8991
Title: A domino type one-flask synthesis of 1-substituted-5-aminoimidazole-4-carboxamides and ring transformation to pyrazine under microwave through suitable aminoimidazoliumcarboxamide
Authors: Chattopadhyay, Gautam
Saha, Tapas K
Issue Date: Apr-2005
Publisher: CSIR
Series/Report no.: <b style=""> Int.Cl.<sup>7</sup> C 07 D 233/54</b>
Abstract: Reductive heterocyclisation of oximinocyanoacetamide <b style="">1</b> in the presence of ethyl orthoformate and appropriate amine affords 1-substituted-5-aminoimidazole-4-carboxamides <b style="">2</b>. 4-Amino-5-carboxamido-3-diphenylmethyl-1-phenacylimidazolium bromide <b style="">4c</b>, generated <i style="">in situ</i> from <b style="">2i</b>, furnishes a ring expanded pyrazine derivative, 3-(1-amino-1-diphenylmethylamino)methyleno-2-oxo-6-phenylpyrazine <b style="">5</b> with methanolic alkali under microwave in excellent yield.
Description: 827-830
URI: http://hdl.handle.net/123456789/8991
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(04) [April 2005]

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