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Title: A domino type one-flask synthesis of 1-substituted-5-aminoimidazole-4-carboxamides and ring transformation to pyrazine under microwave through suitable aminoimidazoliumcarboxamide
Authors: Chattopadhyay, Gautam
Saha, Tapas K
Issue Date: Apr-2005
Publisher: CSIR
Series/Report no.:  Int.Cl.7 C 07 D 233/54
Abstract: Reductive heterocyclisation of oximinocyanoacetamide 1 in the presence of ethyl orthoformate and appropriate amine affords 1-substituted-5-aminoimidazole-4-carboxamides 2. 4-Amino-5-carboxamido-3-diphenylmethyl-1-phenacylimidazolium bromide 4c, generated in situ from 2i, furnishes a ring expanded pyrazine derivative, 3-(1-amino-1-diphenylmethylamino)methyleno-2-oxo-6-phenylpyrazine 5 with methanolic alkali under microwave in excellent yield.
Description: 827-830
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(04) [April 2005]

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