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IJCT Vol.15(2) [March 2008] >


Title: Spectrophotometric determination of eprosartan mesylate in raw material and experimental tablets
Authors: Kamila, M M
Mondal, N
Ghosh, L K
Keywords: Eprosartan mesylate
UV spectrophotometry
Issue Date: Mar-2008
Publisher: CSIR
Abstract: A simple, sensitive and accurate UV spectrophotometric method has been developed for the determination of eprosartan mesylate in raw material and experimental tablets. Beer’s law was obeyed in the concentration range 2-30 μg mL⁻¹ for the drug (λ = 232 nm) with an apparent molar absorptivity and Sandell sensitivity of 2.8 × 10⁴ L.mol⁻¹cm⁻¹ and 0. 01854 µg cm⁻²/0.001A, respectively. The limits of detection and quantitation were calculated to be 0.3623 and 1.098 µg mL⁻¹, respectively. Results were validated statistically according to ICH guidelines. Validation of the method yielded good results in the concerning range (2-30 µg mL⁻¹), linearity (r² = 0.9998), precision and accuracy. The excipients present in the experimental tablets did not interfere with the method.
Page(s): 194-196
ISSN: 0971–457X
Source:IJCT Vol.15(2) [March 2008]

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