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Title: One pot synthesis of 3,4-dihydropyrimidin-2(1H)-ones/-thiones catalysed by zinc chloride: An improved procedure for the Biginelli reaction using microwaves under solvent free condition
Authors: Pasha, M A
Swamy, N Ramachandra
Jayashankara, V P
Issue Date: Apr-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D 239/00
Abstract: Zinc chloride efficiently catalyzes the three-component coupling of β-keto ester, substituted aldehyde and urea or thiourea to afford the corresponding 3,4-dihydropyrimidin-2(1H)-ones/thiones respectively, the new protocol for the Biginelli reaction under microwave irradiation works in the absence of solvent, the yields are high and the reaction goes to completion within 20-35 sec.
Page(s): 823-826
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(04) [April 2005]

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