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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >
| Title: | Novel bridgehead nitrogen bisheterocyclic systems: Synthesis, stereochemistry and antimicrobial activity of p-bis[2H, 5H-4-oxo-thiazol-3-yl]phenylenes and p-bis[cis-5H-3,3a-dihydropyrazolo[3,4-d]thiazol-6-yl]phenylenes |
| Authors: | Mohan, Jag
Kumar, Ashok |
| Issue Date: | Mar-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D // A 61 P 31/04, 31/10 |
| Abstract: | The facile synthesis of p-bis[cis-3,3a-dihydro-5H-pyrazolo[3,4-d]thiazol-6-yl]phenylenes
4 has been achieved by the condensation of p-bis[4-substituted
phenylimine]phenylenes 1 with thioglycollic acid in toluene, using
Dean-Stark water separator, to give p-bis[2H,5H-4-oxo-2-(p-substituted
phenyl)thiazol-3-yl]phenylene 2, which on condensation with arylaldehydes
furnishes 5-arylidene derivatives 3 followed by treatment with
2,4-dinitrophenylhydrazine. The antibacterial and antifungal activities of some
of the compounds have also been evaluated. |
| Page(s): | 631-634 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(03) [March 2005]
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