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Title: Novel bridgehead nitrogen bisheterocyclic systems: Synthesis, stereochemistry and antimicrobial activity of <i>p-bis</i>[2<i>H</i>, 5<i>H</i>-4-oxo-thiazol-3-yl]phenylenes and <i>p-bis</i>[<i>cis</i>-5<i>H</i>-3,3a-dihydropyrazolo[3,4-<i>d</i>]thiazol-6-yl]phenylenes
Authors: Mohan, Jag
Kumar, Ashok
Issue Date: Mar-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D // A 61 P 31/04, 31/10</b>
Abstract: The facile synthesis of <i>p-bis</i>[<i>cis</i>-3,3a-dihydro-5<i>H</i>-pyra­zolo[3,4-<i>d</i>]thiazol-6-yl]phenylenes <b>4</b> has been achieved by the condensation of <i>p-bis</i>[4-substituted phenylimine]phenylenes <b>1</b> with thioglycollic acid in toluene, using Dean-Stark water separator, to give <i>p-bis</i>[2H,5<i>H</i>-4-oxo-2-(<i>p</i>-substituted phenyl)­thiazol-3-yl]phenylene <b>2</b>, which on condensation with aryl­aldehydes furnishes 5-arylidene derivatives <b>3</b> followed by treatment with 2,4-dinitrophenylhydrazine. The antibacterial and antifungal activities of some of the compounds have also been evaluated.
Description: 631-634
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(03) [March 2005]

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