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|Title:||Novel bridgehead nitrogen bisheterocyclic systems: Synthesis, stereochemistry and antimicrobial activity of p-bis[2H, 5H-4-oxo-thiazol-3-yl]phenylenes and p-bis[cis-5H-3,3a-dihydropyrazolo[3,4-d]thiazol-6-yl]phenylenes|
|IPC Code:||Int.Cl.7 C 07 D // A 61 P 31/04, 31/10|
|Abstract:||The facile synthesis of p-bis[cis-3,3a-dihydro-5H-pyrazolo[3,4-d]thiazol-6-yl]phenylenes 4 has been achieved by the condensation of p-bis[4-substituted phenylimine]phenylenes 1 with thioglycollic acid in toluene, using Dean-Stark water separator, to give p-bis[2H,5H-4-oxo-2-(p-substituted phenyl)thiazol-3-yl]phenylene 2, which on condensation with arylaldehydes furnishes 5-arylidene derivatives 3 followed by treatment with 2,4-dinitrophenylhydrazine. The antibacterial and antifungal activities of some of the compounds have also been evaluated.|
|Appears in Collections:||IJC-B Vol.44B(03) [March 2005]|
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