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Title: Novel bridgehead nitrogen bisheterocyclic systems: Synthesis, stereochemistry and antimicrobial activity of p-bis[2H, 5H-4-oxo-thiazol-3-yl]phenylenes and p-bis[cis-5H-3,3a-dihydropyrazolo[3,4-d]thiazol-6-yl]phenylenes
Authors: Mohan, Jag
Kumar, Ashok
Issue Date: Mar-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D // A 61 P 31/04, 31/10
Abstract: The facile synthesis of p-bis[cis-3,3a-dihydro-5H-pyra­zolo[3,4-d]thiazol-6-yl]phenylenes 4 has been achieved by the condensation of p-bis[4-substituted phenylimine]phenylenes 1 with thioglycollic acid in toluene, using Dean-Stark water separator, to give p-bis[2H,5H-4-oxo-2-(p-substituted phenyl)­thiazol-3-yl]phenylene 2, which on condensation with aryl­aldehydes furnishes 5-arylidene derivatives 3 followed by treatment with 2,4-dinitrophenylhydrazine. The antibacterial and antifungal activities of some of the compounds have also been evaluated.
Page(s): 631-634
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(03) [March 2005]

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