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|Title:||Synthesis of imidazole, coumarin and isoxazole containing new triheterocyclic compounds and their derivatives|
|IPC Code:||Int.Cl.7 C 07 D 261/00, 233/54, 311/10|
|Abstract:||Reaction of substituted 4-amino-3-methyl-5-styrylisoxazoles 1 with 3-(2-bromoacetyl)coumarin 2 in abs. ethanol leads to the formation of 3-[2-(3-methyl-5-styryl-4-ylamino)acetyl]chromen-2-ones 3, which are subsequently cyclised by treatment with KSCN to 3-[1-(3-methyl-5-styryl-isoxazol-4-yl)-2-mercapto-1H-imidazol-4-yl]-1-benzopyran-2H-ones 4. 2-Mercaptoimidazoles 4 on treatment with ClCH2COCl in DMF / abs. ethanol give unexpected product esters 5. The reaction of 4 with phenacyl bromides results in the formation of thioethers 6.|
|Appears in Collections:||IJC-B Vol.44B(03) [March 2005]|
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