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Title: Synthesis of imidazole, coumarin and isoxazole containing new triheterocyclic compounds and their derivatives
Authors: Rajanarendar, E
Karunakar, D
Srinivas, M
Issue Date: Mar-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D 261/00, 233/54, 311/10
Abstract: Reaction of substituted 4-amino-3-methyl-5-styrylisoxazoles 1 with 3-(2-bromoacetyl)coumarin 2 in abs. ethanol leads to the formation of 3-[2-(3-methyl-5-styryl-4-ylamino)acetyl]chromen-2-ones 3, which are subsequently cyclised by treatment with KSCN to 3-[1-(3-methyl-5-styryl-isoxazol-4-yl)-2-mercapto-1H-imidazol-4-yl]-1-benzopyran-2H-ones 4. 2-Mercaptoimidazoles 4 on treatment with ClCH2COCl in DMF / abs. ethanol give unexpected product esters 5. The reaction of 4 with phenacyl bromides results in the formation of thioethers 6.
Page(s): 563-567
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(03) [March 2005]

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