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|Title:||Enantioselective synthesis of (S)--arylpropionic acids via Pd-catalyzed kinetic resolution of benzylic alcohols|
|Authors:||Thakur, Vinay V|
|IPC Code:||Int.Cl.7 C 07 C 53/122|
|Abstract:||A convenient synthetic route for the synthesis of three (S)-a-propionic acids, (S)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (S)-phenylpropionic acid (92% ee) is described. Pd-catalyzed oxidative kinetic resolution of the corresponding benzylic alcohols is used as a key step to introduce stereogenicity into the molecule.|
|Appears in Collections:||IJC-B Vol.44B(03) [March 2005]|
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