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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >
| Title: | Enantioselective synthesis of (S)- -arylpropionic acids via Pd-catalyzed kinetic resolution of benzylic alcohols |
| Authors: | Thakur, Vinay V
Sudalai, A |
| Issue Date: | Mar-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C 53/122 |
| Abstract: | A convenient synthetic route for the
synthesis of three (S)-a-propionic
acids, (S)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (S)-phenylpropionic acid (92% ee) is
described. Pd-catalyzed oxidative kinetic resolution of the corresponding
benzylic alcohols is used as a key step to introduce stereogenicity into the
molecule. |
| Page(s): | 557-562 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(03) [March 2005]
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