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IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >

Title: Enantioselective synthesis of (S)--arylpropionic acids via Pd-catalyzed kinetic resolution of benzylic alcohols
Authors: Thakur, Vinay V
Sudalai, A
Issue Date: Mar-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 C 53/122
Abstract: A convenient synthetic route for the synthesis of three (S)-a-propionic acids, (S)-naproxen (90% ee), (S)-ibuprofen (82% ee) and (S)-phenylpropionic acid (92% ee) is described. Pd-catalyzed oxidative kinetic resolution of the corresponding benzylic alcohols is used as a key step to introduce stereogenicity into the molecule.
Page(s): 557-562
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(03) [March 2005]

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