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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >
| Title: | A chiral pool based synthetic strategy for  -hydroxyalkyl- 2-butenolides |
| Authors: | Sengupta, Saumitra
Mondal, Somnath |
| Issue Date: | Mar-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 307/26 |
| Abstract: | A new stereoselective synthetic route to a -hydroxyalkyl-2-butenolide has been described starting from the  -hydroxy acid
chiral pool and via the intermediacy of an enantiopure -hydroxy- -ketosulfone. A
non-chelation controlled borohydride reduction (80% de) step is the key to the
high diastereoselectivity observed in this synthesis. |
| Page(s): | 553-556 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(03) [March 2005]
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