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|Title:||A chiral pool based synthetic strategy for -hydroxyalkyl-2-butenolides|
|IPC Code:||Int.Cl.7 C 07 D 307/26|
|Abstract:||A new stereoselective synthetic route to a -hydroxyalkyl-2-butenolide has been described starting from the -hydroxy acid chiral pool and via the intermediacy of an enantiopure -hydroxy--ketosulfone. A non-chelation controlled borohydride reduction (80% de) step is the key to the high diastereoselectivity observed in this synthesis.|
|Appears in Collections:||IJC-B Vol.44B(03) [March 2005]|
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