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Title: A chiral pool based synthetic strategy for <img src='/image/spc_char/gamma.gif' border=0>-hydroxyalkyl-<img src='/image/spc_char/delta.gif' border=0><sup>2</sup>-butenolides
Authors: Sengupta, Saumitra
Mondal, Somnath
Issue Date: Mar-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 307/26</b>
Abstract: A new stereoselective synthetic route to a <img src='/image/spc_char/gamma.gif' border=0>-hydroxyalkyl-<img src='/image/spc_char/delta.gif' border=0><sup>2</sup>-butenolide has been described starting from the <img src='/image/spc_char/alpha.gif' border=0> -hydroxy acid chiral pool and via the intermediacy of an enantiopure <img src='/image/spc_char/gamma.gif' border=0>-hydroxy-<img src='/image/spc_char/beta.gif' border=0>-ketosulfone. A non-chelation controlled borohydride reduction (80% de) step is the key to the high diastereoselectivity observed in this synthesis.
Description: 553-556
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(03) [March 2005]

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