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Title: Synthesis, characterization and evaluation of antimicrobial activity of Mannich bases of some 2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones
Authors: Altıntaş, Handan
Ateş, Öznur
Kocabalkanli, Ayşe
Birteksöz, Seher
Ötük, Gülten
Issue Date: Mar-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D // A 61 P 31/04, 31/10
Abstract: A series of 5-(N,N-disubstituted aminomethyl)-2-[(4-carbethoxymethylthiazol-2-yl)imino]-4-thiazolidinones 4a-m have been synthesized. Their structures are confirmed by elemental analyses and spectral data (IR, 1H NMR, EIMS). The antibacterial activities of the compounds against Staphylococcus aureus ATCC 6538, Staphylococcus epidermidis ATCC 12228, Escherichia coli ATCC 8739, Klebsiella pneumoniae ATCC 4352, Pseudomonas aeruginosa ATCC 1539, Salmonella typhi, Shigella flexneri, Proteus mirabilis ATCC 14153 and antifungal activity against Candida albicans ATCC 10231 are tested using disk diffusion method. Some of the compounds are found to have significant activity against S. aureus ATCC 6538.
Page(s): 585-590
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(03) [March 2005]

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