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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >
| Title: | Synthesis of triphenylmethane derivative: Bisacodyl |
| Authors: | Mereyala, Hari Babu
Sambaru, Kalyani |
| Issue Date: | Mar-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C 15/14 |
| Abstract: | A new method for the
synthesis of bisacodyl 1 is
described. The key step involves migration of 2-pyridacyl group of phenyl
pyridine-2-carboxylate 4 in AlCl3
at 160 oC to yield the intermediate
4-hydroxyphenyl (2-pyridyl) ketone 5a. The reaction of 5a with phenol using H3PO4
gives 1. This method has advantage over the existing literature methods
because easily available pyridine-2-carboxylic acid is used as a starting
material instead of the less stable pyridine-2-carboxaldehyde. |
| Page(s): | 615-617 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(03) [March 2005]
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