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IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >


Title: Synthesis of triphenylmethane derivative: Bisacodyl
Authors: Mereyala, Hari Babu
Sambaru, Kalyani
Issue Date: Mar-2005
Publisher: CSIR
IPC Code Int.Cl.7 C 07 C 15/14
Abstract: A new method for the synthesis of bisacodyl 1 is described. The key step involves migration of 2-pyridacyl group of phenyl pyridine-2-carboxylate 4 in AlCl3 at 160 oC to yield the intermediate 4-hydroxyphenyl (2-pyridyl) ketone 5a. The reaction of 5a with phenol using H3PO4 gives 1. This method has advantage over the existing literature methods because easily available pyridine-2-carboxylic acid is used as a starting material instead of the less stable pyridine-2-carboxaldehyde.
Page(s): 615-617
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(03) [March 2005]

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