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|Title:||Synthesis of triphenylmethane derivative: Bisacodyl|
|Authors:||Mereyala, Hari Babu|
|Series/Report no.:||Int.Cl.7 C 07 C 15/14|
|Abstract:||A new method for the synthesis of bisacodyl 1 is described. The key step involves migration of 2-pyridacyl group of phenyl pyridine-2-carboxylate 4 in AlCl3 at 160 oC to yield the intermediate 4-hydroxyphenyl (2-pyridyl) ketone 5a. The reaction of 5a with phenol using H3PO4 gives 1. This method has advantage over the existing literature methods because easily available pyridine-2-carboxylic acid is used as a starting material instead of the less stable pyridine-2-carboxaldehyde.|
|Appears in Collections:||IJC-B Vol.44B(03) [March 2005]|
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