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IJC-B Vol.44B(03) [March 2005] >

Title: Synthesis and antimicrobial activity of 1,3,5-thiadiazines and their isomerism into 1,3,5-triazines
Authors: Deohate, Pradip P
Berad, B N
Issue Date: Mar-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 D 285/34 // A61 P 31/04
Abstract: A series of 2,6-diphenylimino-4-(substituted)-benzylidene amino-1,3,5-thiadiazines 4a-g have been obtained by the basification of their hydrochlorides 3a-g, which are prepared by interaction of N-phenyl isocyanodichloride and 1-(substituted)- benzylidene amidino-3-phenyl thiocarbamides 2a-g. The latter have been synthesized by the condensation of 1-amidino-3-phenyl thiocarbamide 1 and different aliphatic and aromatic aldehydes. Compounds 4a-g on acylation afford monoacetyl derivatives 5a-g, on reaction with sodium nitrite in acidic medium afforded mononitroso derivatives 6a-g, and on boiling with 5% aqueous ethanolic (1:1) sodium hydroxide solution isomerize into corresponding 1-phenyl-2-phenylimino-4-(substituted)-benzyl¬≠idene amino-6-thio-1,3,5-triazines 7a-g. The title compounds have been assayed for their antimicrobial activity against gram-positive as well as gram-negative microorganisms.
Page(s): 638-642
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(03) [March 2005]

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