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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >
| Title: | QSAR analysis of a few GABA aminotransferase inhibitors as potent antiepileptics |
| Authors: | Kanth, M S Vijay
Chaturvedi, S C |
| Issue Date: | Mar-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C 229/00 |
| Abstract: | Quantitative structure activity relationship
(QSAR) analysis of GABA analogs as GABA-AT inhibitors has been performed using
various physicochemical parameters. Attempt has been made to explore the
structural and/or physicochemical requirements of the compounds that are
responsible for the inhibitory activity. Statistically significant equations
are obtained which are cross-validated and subjected to ANOVA analysis to prove
their efficacy. Significant models obtained show that Non 1,4 van der Waal’s
energy, HOMO energy, LogP, Connolly Accessible Area and Total Energy of the
molecules are the important parameters or properties that have to be considered
while developing potent GABA-AT inhibitors as they are the deciding factors for
its potent activity. |
| Page(s): | 595-599 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(03) [March 2005]
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