NISCAIR Online Periodicals Repository

NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR)  >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(03) [March 2005] >


Title: QSAR analysis of a few GABA aminotransferase inhibitors as potent antiepileptics
Authors: Kanth, M S Vijay
Chaturvedi, S C
Issue Date: Mar-2005
Publisher: CSIR
IPC Code Int.Cl.7 C 07 C 229/00
Abstract: Quantitative structure activity relationship (QSAR) analysis of GABA analogs as GABA-AT inhibitors has been performed using various physicochemical parameters. Attempt has been made to explore the structural and/or physicochemical requirements of the compounds that are responsible for the inhibitory activity. Statistically significant equations are obtained which are cross-validated and subjected to ANOVA analysis to prove their efficacy. Significant models obtained show that Non 1,4 van der Waal’s energy, HOMO energy, LogP, Connolly Accessible Area and Total Energy of the molecules are the important parameters or properties that have to be considered while developing potent GABA-AT inhibitors as they are the deciding factors for its potent activity.
Page(s): 595-599
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(03) [March 2005]

Files in This Item:

File Description SizeFormat
IJCB 44B(3) 595-599.pdf108.62 kBAdobe PDFView/Open
 Current Page Visits: 583 
Recommend this item

 

National Knowledge Resources Consortium |  NISCAIR Website |  Contact us |  Feedback

Disclaimer: NISCAIR assumes no responsibility for the statements and opinions advanced by contributors. The editorial staff in its work of examining papers received for publication is helped, in an honorary capacity, by many distinguished engineers and scientists.

CC License Except where otherwise noted, the Articles on this site are licensed under Creative Commons License: CC Attribution-Noncommercial-No Derivative Works 2.5 India

Copyright © 2012 The Council of Scientific and Industrial Research, New Delhi. All rights reserved.

Powered by DSpace Copyright © 2002-2007 MIT and Hewlett-Packard | Compliant to OAI-PMH V 2.0

Home Page Total Visits: 558642 since 06-Feb-2009  Last updated on 30-Jul-2014Webmaster: nopr@niscair.res.in