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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(02) [February 2005] >
| Title: | Facile synthesis of some new azetidinones and acetyl oxadiazoles bearing benzo[b]thiophene nucleus as a potent biological active agent |
| Authors: | Vasoya, S L
Patel, M R
Dobaria, S V
Joshi, H S |
| Issue Date: | Feb-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 333/52 // A 61 P 31/06, 31/04 |
| Abstract: | 2-Hydrazinocarbonyl-3-chloro-5-phenoxybenzo[b]thiophene
1 has been prepared by the condensation of 3-chloro-5-phenoxybenzo[b]thiophenoyl
chloride with hydrazine hydrate. Compound 1 on condensation with
aromatic aldehyde furnishes 2-substituted
benzalhydrazinocarbonyl-3-chloro-5-phenoxybenzo[b]thiophenes 2a-l, which
on further cyclocondensation with chloroacetyl chloride in the presence of
triethyl amine afford 4-aryl-3-chloro-1-(3'-chloro-5'-phenoxy-2'-benzo[b]thiophenoylamino)-2-azetidinones 3a-l. Compounds 2a-l
on reaction with acetic anhydride yield 2-(3'-chloro-5'-phenoxybenzo[b]thiophene-2'-yl)-4-acetyl-5-aryl-4,5-dihydro-1,3,4-oxadiazoles 4a-l. The
structures of the compounds 2a-l, 3a-l and 4a-l have been
confirmed by elemental analysis and IR, 1H NMR and mass
spectral data. All the compounds have been screened for their antitubercular
activity towards Mycobacterium tuberculosis H37Rv and
antimicrobial activity against different microbes. |
| Page(s): | 405-409 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(02) [February 2005]
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