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|Title:||Synthesis of 5,6,7,3'-tetramethoxy-4'-hydroxy-8-C-prenylflavone|
|Authors:||Hossain, M Amzad|
|IPC Code:||Int.Cl.7 C 07 D 311/30|
|Abstract:||5,6,7,3-Tetramethoxy-4'-hydroxy-8-C-prenylflavone5 isolated from the leaves of Malaysian Orthosiphon stamineus has been synthesized by synthetic route. 2,4,5,6-Tetrahydroxyacetophenone 1 on treatment with dimethyl sulphate affords 2-hydroxy-4, 5, 6-trimethoxyacetophenone 2 and several other minor compounds. Compound 2 on prenylation yields 2-hydroxy-4,5,6-trimethoxy-3-C-prenylacetophenone 3. Alkaline condensation of 3 and 3-methoxy-4-hydroxybenzaldehyde affords 2',4-dihydroxy-3,4',5',6'-tetramethoxy-8-C-prenylchalcone 4. 2,3-Dichloro-5,6-dicyano-1,4-benzoquinone (DDQ) treatment of 4 furnishes the title compound 5.|
|Appears in Collections:||IJC-B Vol.44B(02) [February 2005]|
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