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Title: Synthesis and pharmacological evaluation of 2-(3’,5’-dichlorobenzo[b]thiophen-2’-yl)-5-arylamino-1,3,4-thiadiazoles
Authors: Thaker, K M
Joshi, H S
Issue Date: Feb-2005
Publisher: CSIR
Series/Report no.: Int.Cl.7 C 07 D 285/12
Abstract: The condensation of 2-hydrazinocarbonyl-3,5-dichlorobenzo[b]thiophene 1 with different arylisothiocyanate yields N1-(3,5-dichlorobenzo[b]thiophen-2-yl)-N4-substituted arylthiosemicarbazides 2a-j. Reaction of 2a-j with conc. H2SO4 affords the corresponding 2-(3’,5’-dichlorobenzo[b]thiophen-2’-yl)-5-arylamino-1,3,4-thiadiazoles 3a-j. The pharmacological evaluations have been performed for their antimicrobial and antitubercular activities.
Description: 410-412
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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