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Title: Synthesis and pharmacological evaluation of 2-(3’,5’-dichlorobenzo[b]thiophen-2’-yl)-5-arylamino-1,3,4-thiadiazoles
Authors: Thaker, K M
Joshi, H S
Issue Date: Feb-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 285/12</b>
Abstract: The condensation of 2-hydrazinocarbonyl-3,5-dichlorobenzo[b]thiophene <b>1</b> with different arylisothiocyanate yields N<sup>1</sup>-(3,5-dichlorobenzo[b]thiophen-2-yl)-N<sup>4</sup>-substituted arylthiosemicarbazides <b>2a-j</b>. Reaction of <b>2a-j</b> with conc. H<sub>2</sub>SO<sub>4</sub> affords the corresponding 2-(3’,5’-dichlorobenzo[b]thiophen-2’-yl)-5-arylamino-1,3,4-thiadiazoles <b>3a-j</b>. The pharmacological evaluations have been performed for their antimicrobial and antitubercular activities.
Description: 410-412
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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