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Title: Isolation, antihypertensive activity and structure activity relationship of flavonoids from three medicinal plants
Authors: Ahmed, Bahar
Howiriny, Tawfeq A Al
Mossa, Jaber S
Tahir, K E H EL
Issue Date: Feb-2005
Publisher: CSIR
IPC Code: Int.Cl.7 C 07 D 311/30
Abstract: Eight flavonoids, namely naringenin 1, 3-β-hydroxynaringenin designated as isoaromadendrin 2, taxifolin 3, isoaromadendrin-7-O-β-D-glucopyranoside designated as isosinensin 4 have been isolated from Euphorbia cuneata Vahl; 5-hydroxy-3, 4′, 7-trimethoxyflavone 5, 5-hydroxy-3, 3′, 4′, 7-tetramethoxyflavone (retusin) 6, 4′, 5-dihydroxyflavone-5-O-β-D-glucopyranoside named as verbenacoside 7 are obtained from Salvia verbenaca L; and epicatchin 8 is isolated from Osyris abyssinica. Their structures have been established by spectral and chemical methods, whereupon the compounds 2, 4 and 7 are found to be new flavonoids. Compounds 1-5, 7, 8 and alcoholic extract of Salvia verbenaca have also been screened biologically for antihypertensive activity in normotensive albino rats, which showed a varied degree in the decrease of blood pressure and heart rate. The flavonoids 2, 3 and 5 are found most potent exhibiting the decrease in blood pressure 36.5, 20.0 and 30.0 (mmHg) respectively in comparison to normal values. Other compounds also exhibit a good activity. The structure activity relationship (SAR) has also been discussed.
Page(s): 400-404
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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