24-May-2013
10:51:27 IST
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Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(02) [February 2005] >
| Title: | Isolation, antihypertensive activity and structure activity relationship of flavonoids from three medicinal plants |
| Authors: | Ahmed, Bahar
Howiriny, Tawfeq A Al
Mossa, Jaber S
Tahir, K E H EL |
| Issue Date: | Feb-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 311/30 |
| Abstract: | Eight flavonoids, namely naringenin 1,
3-β-hydroxynaringenin designated as isoaromadendrin 2, taxifolin 3,
isoaromadendrin-7-O-β-D-glucopyranoside
designated as isosinensin 4 have been isolated from Euphorbia cuneata
Vahl; 5-hydroxy-3, 4′, 7-trimethoxyflavone 5, 5-hydroxy-3, 3′, 4′,
7-tetramethoxyflavone (retusin) 6, 4′, 5-dihydroxyflavone-5-O-β-D-glucopyranoside named as verbenacoside
7 are obtained from Salvia verbenaca L; and epicatchin 8
is isolated from Osyris abyssinica. Their structures have been
established by spectral and chemical methods, whereupon the compounds 2,
4 and 7 are found to be new flavonoids. Compounds 1-5, 7, 8
and alcoholic extract of Salvia verbenaca have also been screened
biologically for antihypertensive activity in normotensive albino rats, which
showed a varied degree in the decrease of blood pressure and heart rate. The
flavonoids 2, 3 and 5 are found most potent exhibiting the
decrease in blood pressure 36.5, 20.0 and 30.0 (mmHg) respectively in
comparison to normal values. Other compounds also exhibit a good activity. The
structure activity relationship (SAR) has also been discussed. |
| Page(s): | 400-404 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(02) [February 2005]
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