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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(02) [February 2005] >
| Title: | Synthesis, characterization and antimicrobial activities of some fluorine containing 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-chlorochromones, 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)chromones and 5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydropyrazolines |
| Authors: | Joshi, N S
Shaikh, A A
Deshpande, A P
Karale, B K
Bhirud, S B
Gill, C H |
| Issue Date: | Feb-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 231/00 // A 61 P 31/04, 31/10 |
| Abstract: | Base catalyzed
condensation of 1 with 2gives compound 3
[1-(5-fluoro-2-hydroxyphenyl)-3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-2-propen-1-one].
On oxidative cyclization with DMSO-CuCl2
3 gives 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-chloro-6-fluorochromones
4. On cyclization with
DMSO-I2, 3 gives
2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)- 6-fluorochromones 5.
When 3 is heated with hydrazine in dioxane gives 6 [5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-(5-fluoro-2-hydroxyphenyl)-4,5-dihydropyrazolines. The
products 3, 4, 5 and 6 are characterized by spectral and elemental analysis. Compounds 3,
4 and 6 are tested for their
antimicrobial activities. |
| Page(s): | 422-425 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(02) [February 2005]
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