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Title: Synthesis, characterization and antimicrobial activities of some fluorine containing 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-chloro­chromones, 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)chromones and 5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-(2-hydroxyphenyl)-4,5-dihydropyrazolines
Authors: Joshi, N S
Shaikh, A A
Deshpande, A P
Karale, B K
Bhirud, S B
Gill, C H
Issue Date: Feb-2005
Publisher: CSIR
IPC Code:  Int.Cl.7 C 07 D 231/00 // A 61 P 31/04, 31/10
Abstract: Base catalyzed condensation of 1 with 2gives compound 3 [1-(5-fluoro-2-hydroxyphenyl)-3-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-2-propen-1-one]. On oxidative cyclization  with DMSO-CuCl2 3 gives 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-chloro-6-fluoro­chro­­m­­ones 4. On cyclization with DMSO-I2, 3 gives 2-(1-phenyl-3-aryl-1H-pyrazol-4-yl)- 6-fluorochromones 5. When 3 is heated with hydrazine in dioxane gives 6 [5-(1-phenyl-3-aryl-1H-pyrazol-4-yl)-3-(5-fluoro-2-hydroxyphenyl)-4,5-dihydropyra­zo­lines. The pro­­ducts 3, 4, 5 and 6 are characterized by spectral and elemental analysis. Compounds 3, 4 and 6 are tested for their antimicrobial activities.
Page(s): 422-425
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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