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Title: Synthesis of <i>syn</i>-<i>N</i>-aryl sulfonyl-4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates and their conversion to <i>ant</i>-form using DBU
Authors: Madhusudhan, G
Reddy, G Om
Ramanatham, J
Dubey, P K
Issue Date: Feb-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 263/00 // A 61 P 31/04</b>
Abstract: Novel <i>syn</i>-<i>N</i>-arylsulfonyl-4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates have been synthesized from the corresponding <img src='/image/spc_char/beta.gif' border=0>-azido alcohols and converted to their <i>anti-</i>form by epimerizing C-2 proton using DBU. Studies on the stabilization energies are done to evaluate conversion from <i>syn</i>-to <i>anti</i>-and not the vice-versa. All the compounds have been tested for their <i>in vitro </i>anti-bacterial activity against <i>S. aureus</i>, <i>E. faecalis</i> and <i>E. faecium.</i>
Description: 366-371
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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