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Title: Synthesis of syn-N-aryl sulfonyl-4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates and their conversion to ant-form using DBU
Authors: Madhusudhan, G
Reddy, G Om
Ramanatham, J
Dubey, P K
Issue Date: Feb-2005
Publisher: CSIR
Series/Report no.: Int.Cl.7 C 07 D 263/00 // A 61 P 31/04
Abstract: Novel syn-N-arylsulfonyl-4-substituted phenyl-2-oxo-1,3-oxazolidine-5-carboxylates have been synthesized from the corresponding -azido alcohols and converted to their anti-form by epimerizing C-2 proton using DBU. Studies on the stabilization energies are done to evaluate conversion from syn-to anti-and not the vice-versa. All the compounds have been tested for their in vitro anti-bacterial activity against S. aureus, E. faecalis and E. faecium.
Description: 366-371
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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