Please use this identifier to cite or link to this item: http://nopr.niscair.res.in/handle/123456789/8940
Title: <i style="">Candida rugosa </i>lipase-mediated enantioselective acetylation studies on (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydro-1-benzopyran-4(<i>H</i>)-ones
Authors: Trikha, Smriti
Kumar, Rajesh
Dhawan, Ashish
Poonam
Prasad, Ashok K
Cholli, Ashok L
Olsen, Carl E
Watterson, Arthur C
Parmar, Virinder S
Issue Date: Feb-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 D 311/04</b>
Abstract: <i style="">Candida rugosa </i>lipase, catalyzed enantioselective acetylation reactions have been performed on novel (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydrobenzopyran-4-ones in diisopropyl ether. The <i style="">Candida rugosa </i>lipase-catalyzed acetylations exhibit the enantiomeric separation of the racemic compounds <b style="">5a-g</b>,<b style=""> </b>the enantioselectivity of the reaction has been found to be highly dependent on the structure of the substrate. The enantiomeric excess (<i style="">ee</i>) values are determined by <sup>1</sup>H NMR spectral analysis of their <i style="">O</i>-acetylmandelic acid esters and highest enantiomeric excess obtained is 79% in case of <b style="">5c</b>.
Description: 356-365
URI: http://hdl.handle.net/123456789/8940
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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