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Title: Candida rugosa lipase-mediated enantioselective acetylation studies on (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydro-1-benzopyran-4(H)-ones
Authors: Trikha, Smriti
Kumar, Rajesh
Dhawan, Ashish
Prasad, Ashok K
Cholli, Ashok L
Olsen, Carl E
Watterson, Arthur C
Parmar, Virinder S
Issue Date: Feb-2005
Publisher: CSIR
Series/Report no.: Int.Cl.7 C 07 D 311/04
Abstract: Candida rugosa lipase, catalyzed enantioselective acetylation reactions have been performed on novel (±)-3-arylmethyl-3-hydroxymethyl-2,3-dihydrobenzopyran-4-ones in diisopropyl ether. The Candida rugosa lipase-catalyzed acetylations exhibit the enantiomeric separation of the racemic compounds 5a-g, the enantioselectivity of the reaction has been found to be highly dependent on the structure of the substrate. The enantiomeric excess (ee) values are determined by 1H NMR spectral analysis of their O-acetylmandelic acid esters and highest enantiomeric excess obtained is 79% in case of 5c.
Description: 356-365
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(02) [February 2005]

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