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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(01) [January 2005] >
| Title: | Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones |
| Authors: | Pandey, V K
Gupta, V D
Upadhyay, Mrinalini
Upadhyay, Mridula
Singh, V K
Tandon, Meenal |
| Issue Date: | Jan-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C 59/54 // A 61 P 31/12 |
| Abstract: | Amido/imido
alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on
treatment with benzoic acid in the presence of conc. H2SO4
yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl)
benzoic acids 2. The acid chloride of 2 on reaction with
hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl)
benzoic acid hydrazides 4 which on condensation with an aromatic
aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl)
benzoic acid hydrazones 5. Compounds 5 undergo cyclization with
phenoxy acetic acid in the presence of thionyl chloride in dry benzene to
furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl-benzamido)]-3-phenoxy-4-phenyl-2-azetidinones
6. The antiviral and antifungal activities of 6 have been
reported. |
| Page(s): | 158-162 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(01) [January 2005]
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