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IJC-B Vol.44B(01) [January 2005] >


Title: Synthesis, characterization and biological activity of 1,3,4-substituted 2-azetidinones
Authors: Pandey, V K
Gupta, V D
Upadhyay, Mrinalini
Upadhyay, Mridula
Singh, V K
Tandon, Meenal
Issue Date: Jan-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 C 59/54 // A 61 P 31/12
Abstract: Amido/imido alcohol/2-phenyl-3-hydroxyethylquinazolin-4 (3H) -one 1 on treatment with benzoic acid in the presence of conc. H2SO4 yields m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxoquinazolinyl) benzoic acids 2. The acid chloride of 2 on reaction with hydrazine hydrate affords m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazides 4 which on condensation with an aromatic aldehyde in acetic acid gives m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl) benzoic acid hydrazones 5. Compounds 5 undergo cyclization with phenoxy acetic acid in the presence of thionyl chloride in dry benzene to furnish 1-[m-(aralkylamido/imidoalkyl/2-phenyl-3-ethyl-3H-4-oxo-quinazolinyl-benzamido)]-3-phenoxy-4-phenyl-2-azetidinones 6. The antiviral and antifungal activities of 6 have been reported.
Page(s): 158-162
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(01) [January 2005]

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