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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(01) [January 2005] >
| Title: | Solvent-free synthesis of 2′,3′,5′-tri-O-acetyl -2,6-dichloropurine nucleoside catalyzed by p-toluenesulfonic acid using microwave |
| Authors: | Qu, Guirong
Liu, Qibin |
| Issue Date: | Jan-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 D 473/00 |
| Abstract: | Starting from
tetraacetylribofuranose 1 and
2,6-dichloropurine 2, in the
presence of p-toluenesulfonic acid (p-TsOH), 2′,3′,5′-tri-O-acetyl-2,6-dichloropurine
nucleoside 3 has been synthesized in
microwave oven for the first time. On comparing(→ Comparing) with the
conventional methods, this method has advantages such as shorter reaction time
(4.5min), better yield (83.5%), simple(→simpler) workup and environmental acceptability. |
| Page(s): | 196-197 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(01) [January 2005]
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