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|Title:||Solvent-free synthesis of 2′,3′,5′-tri-O-acetyl -2,6-dichloropurine nucleoside catalyzed by p-toluenesulfonic acid using microwave|
|Series/Report no.:||Int.Cl.7 C 07 D 473/00|
|Abstract:||Starting from tetraacetylribofuranose 1 and 2,6-dichloropurine 2, in the presence of p-toluenesulfonic acid (p-TsOH), 2′,3′,5′-tri-O-acetyl-2,6-dichloropurine nucleoside 3 has been synthesized in microwave oven for the first time. On comparing(→ Comparing) with the conventional methods, this method has advantages such as shorter reaction time (4.5min), better yield (83.5%), simple(→simpler) workup and environmental acceptability.|
|Appears in Collections:||IJC-B Vol.44B(01) [January 2005]|
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