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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(01) [January 2005] >
| Title: | Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)phenyl]formamide: Formal synthesis of formoterol |
| Authors: | Mereyala, Hari Babu
Sambaru, Kalyani |
| Issue Date: | Jan-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 C 07 C |
| Abstract: | Nitration, benzylation followed by bromination of 4- hydroxyacetophenone is described to
obtain nitrobenzyloxyphenacyl bromide derivative 3. Sodiumborohydride
reduction of 3 gives rise to the
diol 6. Reaction of 6 with Ph3P/I2/imidazole
yields styrene derivative 7.
Compound 7 on selective reduction of
the nitro group followed by N-formylation
and epoxidation affords the key intermediate N-[2-benzyloxy-5-(2-oxiranyl)phenyl]formamide 4. |
| Page(s): | 167-169 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(01) [January 2005]
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