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|Title:||Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)phenyl]formamide: Formal synthesis of formoterol|
|Authors:||Mereyala, Hari Babu|
|IPC Code:||Int.Cl.7 C 07 C|
|Abstract:||Nitration, benzylation followed by bromination of 4- hydroxyacetophenone is described to obtain nitrobenzyloxyphenacyl bromide derivative 3. Sodiumborohydride reduction of 3 gives rise to the diol 6. Reaction of 6 with Ph3P/I2/imidazole yields styrene derivative 7. Compound 7 on selective reduction of the nitro group followed by N-formylation and epoxidation affords the key intermediate N-[2-benzyloxy-5-(2-oxiranyl)phenyl]formamide 4.|
|Appears in Collections:||IJC-B Vol.44B(01) [January 2005]|
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