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IJC-B Vol.44B [2005] >
IJC-B Vol.44B(01) [January 2005] >

Title: Synthesis of N-[2-benzyloxy-5-(2-oxiranyl)­phenyl]formamide: Formal synthesis of formoterol
Authors: Mereyala, Hari Babu
Sambaru, Kalyani
Issue Date: Jan-2005
Publisher: CSIR
IPC CodeInt.Cl.7 C 07 C
Abstract: Nitration, benzylation followed by bromination of 4- hydroxy­acetophenone is described to obtain nitrobenzyloxy­phenacyl bromide derivative 3. Sodiumborohydride reduction of 3 gives rise to the diol 6. Reaction of 6 with Ph3P/I2/imidazole yields sty­rene derivative 7. Compound 7 on selective reduction of the nitro group followed by N-formylation and epoxidation affords the key intermediate N-[2-benzyloxy-5-(2-oxiranyl)­phenyl]­formamide 4.
Page(s): 167-169
ISSN: 0975-0983(Online); 0376-4699(Print)
Source:IJC-B Vol.44B(01) [January 2005]

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