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Title: Synthesis of <i style="">N</i>-[2-benzyloxy-5-(2-oxiranyl)­phenyl]formamide: Formal synthesis of formoterol
Authors: Mereyala, Hari Babu
Sambaru, Kalyani
Issue Date: Jan-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> C 07 C</b>
Abstract: Nitration, benzylation<b style=""> </b>followed by bromination of 4<b style="">- </b>hydroxy­acetophenone is described to obtain nitrobenzyloxy­phenacyl bromide derivative<b style=""> 3</b>.<b style=""> </b>Sodiumborohydride reduction of <b style="">3</b> gives rise to the diol <b style="">6</b>. Reaction of <b style="">6</b> with Ph<sub>3</sub>P/I<sub>2</sub>/imidazole yields sty­rene derivative <b style="">7</b>. Compound <b style="">7</b> on selective reduction of the nitro group followed by <i style="">N-</i>formylation and epoxidation affords the key intermediate <i style="">N-[2-</i>benzyloxy-5-(2-oxiranyl)­phenyl]­formamide <b style="">4</b>.
Description: 167-169
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(01) [January 2005]

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