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Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.44B [2005] >
IJC-B Vol.44B(01) [January 2005] >
| Title: | Synthesis and QSAR of O,O-diaryl O-ethyl phosphorothionates for their fungicidal activity against Rhizoctonia solani and Sclerotium rolfsii |
| Authors: | A, Bijul Lakshman
Gupta, R L |
| Issue Date: | Jan-2005 |
| Publisher: | CSIR |
| IPC Code: | Int.Cl.7 A 61K 35/00 // A 61 P 31/10 |
| Abstract: | A series of twenty-one O,O-diaryl O-ethyl
phosphorothionates having different substituents in the phenyl ring have been
synthesized, characterized by various spectroscopic techniques and tested in
vitro for fungicidal activity against Rhizoctonia solani and Sclerotium
rolfsii. Among these, O,O-di(2,4-dimethylphenyl) O-ethyl phosphorothionates
exhibit highest fungicidal activity (ED50 =0.066 mg mL-1,
R. solani and 0.042 mg mL-1, S. rolfsii) The quantitative
structure activity relationship (QSAR) obtained by means of multiple regression
analysis technique using the fungicidal activity data and physico-chemical
parameters of benzene ring substituents reveal that the size and shape of ortho-substituents
expressed in terms of STERIMOL L and B1 parameters i.e, high value of length
parameter, [∑L(o)] and low value of width parameter, [∑B1(o)] favour high
fungicidal activity against both fungi. |
| Page(s): | 152-157 |
| ISSN: | 0975-0983(Online); 0376-4699(Print) |
| Source: | IJC-B Vol.44B(01) [January 2005]
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