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Title: Synthesis and QSAR of O,O-diaryl O-ethyl phosphorothionates for their fungicidal activity against <i style="">Rhizoctonia solani</i> and <i style="">Sclerotium rolfsii</i>
Authors: A, Bijul Lakshman
Gupta, R L
Issue Date: Jan-2005
Publisher: CSIR
Series/Report no.: <b>Int</b>.<b>Cl</b>.<b><sup>7</sup> A 61K 35/00 // A 61 P 31/10</b>
Abstract: A series of twenty-one O,O-diaryl O-ethyl phosphorothionates having different substituents in the phenyl ring have been synthesized, characterized by various spectroscopic techniques and tested <i>in vitro</i> for fungicidal activity against <i>Rhizoctonia solani</i> and <i>Sclerotium rolfsii. </i>Among these, O,O-di(2,4-dimethylphenyl) O-ethyl phosphorothionates exhibit highest fungicidal activity (ED<sub>50 </sub>=0.066 mg mL<sup>-1</sup><i>, R. solani</i> and 0.042 mg mL<sup>-1</sup>, <i>S. rolfsii</i>) The quantitative structure activity relationship (QSAR) obtained by means of multiple regression analysis technique using the fungicidal activity data and physico-chemical parameters of benzene ring substituents reveal that the size and shape of <i>ortho</i>-substituents expressed in terms of STERIMOL L and B1 parameters i.e, high value of length parameter, [∑L(o)] and low value of width parameter, [∑B1(o)] favour high fungicidal activity against both fungi.
Description: 152-157
ISSN: 0975-0983(Online); 0376-4699(Print)
Appears in Collections:IJC-B Vol.44B(01) [January 2005]

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