25-May-2013
23:01:57 IST
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NISCAIR ONLINE PERIODICALS REPOSITORY (NOPR) >
NISCAIR PUBLICATIONS >
Research Journals >
Indian Journal of Chemistry -Section B (IJC-B) >
IJC-B Vol.49B [2010] >
IJC-B Vol.49B(05) [May 2010] >
| Title: | Efficient synthesis of some novel spiro heterocycles containing triazine nucleus and their microbiological activity |
| Authors: | Dabholkar, Vijay V
Tripathi, Dilip Ravi |
| Keywords: | Triazine
thiocarbohydrizide
2-aminothiophenol
triazole |
| Issue Date: | May-2010 |
| Publisher: | CSIR |
| Abstract: |
The compound
4-[(2,4-substituted benzylidine)-amino]-3-thioxo-1,2,4-triazin-5-one 2 is treated with bromine in glacial
acetic acid to yield, 4-[(2,4-substituted benzylidine)-amino]-6,6-dibromo-3-thioxo-1,2,4-triazin-5-one
3. The dibromo compound 3 is then subjected to reaction with
substituted triazoles and amino thiophenol to furnish, 1-thia-2,3-(3′-substituted)-triazolo-4,6,7,9-tetraza-4,6,7-trihydro-8-thioxo-10-oxo-9[(2"/4"
substituted benzylidine)-amino]spiro[4.5]decane 4 and, 1-thia-2,3-(3'-substituted)-benzo-4,6,7,9-tetraza-4,6,7-trihydro-8-thioxo-10-oxo-9[(2"/4"
substituted benzylidine)-amino]spiro[4.5]decane 5, respectively. The compounds have been synthesized by
conventional methods. The IR, 1H NMR, 13C NMR and mass
spectral fragmentation patterns of some prepared compounds have been
investigated to elucidate the structure of the synthesized compounds. The final
compounds have also been screened for microbiological activity, which show some
inhibitory action against gram positive and gram negative micro organisms.
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| Page(s): | 593-597 |
| Source: | IJC-B Vol.49B(05) [May 2010]
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