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Title: Efficient synthesis of some novel spiro heterocycles containing triazine nucleus and their microbiological activity
Authors: Dabholkar, Vijay V
Tripathi, Dilip Ravi
Keywords: Triazine
Issue Date: May-2010
Publisher: CSIR
Abstract:  The compound 4-[(2,4-substituted benzylidine)-amino]-3-thioxo-1,2,4-triazin-5-one 2 is treated with bromine in glacial acetic acid to yield, 4-[(2,4-substituted benzylidine)-amino]-6,6-dibromo-3-thioxo-1,2,4-triazin-5-one 3. The dibromo compound 3 is then subjected to reaction with substituted triazoles and amino thiophenol to furnish, 1-thia-2,3-(3′-substituted)-triazolo-4,6,7,9-tetraza-4,6,7-trihydro-8-thioxo-10-oxo-9[(2"/4" substituted ben­zyli­dine)-amino]spiro[4.5]decane 4 and, 1-thia-2,3-(3'-substituted)-benzo-4,6,7,9-tetraza-4,6,7-trihydro-8-thioxo-10-oxo-9[(2"/4" substituted benzylidine)-amino]spiro[4.5]decane 5, respectively. The compounds have been synthesized by conventional methods. The IR, 1H NMR, 13C NMR and mass spectral fragmentation patterns of some prepared compounds have been investigated to elucidate the structure of the synthesized compounds. The final compounds have also been screened for microbiological activity, which show some inhibitory action against gram positive and gram negative micro organisms.
Page(s): 593-597
Source:IJC-B Vol.49B(05) [May 2010]

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